CATH Domain 6midC02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.67	Viral Envelope Glycoprotein; domain 2
	3.30.67.10	Viral Envelope Glycoprotein, domain 2

Domain Context

CATH Clusters

Superfamily	Viral Envelope Glycoprotein, domain 2
Functional Family

Enzyme Information

3.6.1.15	Nucleoside-triphosphate phosphatase. based on mapping to UniProt A0A024B7W1 NTP + H(2)O = NDP + phosphate. -!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
2.1.1.56	mRNA (guanine-N(7)-)-methyltransferase. based on mapping to UniProt A0A024B7W1 S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA. -!- Adds an N(7)-methylguanine cap to mRNA. -!- The nucleoside next to the terminal guanosine may be either guanosine or adenosine.
3.4.21.91	Flavivirin. based on mapping to UniProt A0A024B7W1 Selective hydrolysis of -Xaa-Xaa-\|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
3.6.4.13	RNA helicase. based on mapping to UniProt A0A024B7W1 ATP + H(2)O = ADP + phosphate. -!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).
2.1.1.57	Methyltransferase cap1. based on mapping to UniProt A0A024B7W1 S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)- (purine-ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)- methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)- [mRNA]. -!- This enzyme catalyzes the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules, which may be either guanosine or adenosine. -!- This methylation event is known as cap1, and occurs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses. -!- The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine. -!- Formerly EC 2.1.1.58.
2.7.7.48	RNA-directed RNA polymerase. based on mapping to UniProt A0A024B7W1 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.

UniProtKB Entries (1)

POLG_ZIKVF

Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013

Genome polyprotein

PDB Structure

PDB	6MID
External Links	PDBSum Proteopedia
Method	ELECTRON MICROSCOPY
Organism
Primary Citation	Structural basis of a potent human monoclonal antibody against Zika virus targeting a quaternary epitope. Long, F., Doyle, M., Fernandez, E., Miller, A.S., Klose, T., Sevvana, M., Bryan, A., Davidson, E., Doranz, B.J., Kuhn, R.J., Diamond, M.S., Crowe Jr., J.E., Rossmann, M.G. Proc. Natl. Acad. Sci. U.S.A.