CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.630 | Cytochrome p450 |
|
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
| Superfamily | Cytochrome P450 |
| Functional Family | Cholesterol side-chain cleavage enzyme, mitochondrial |
Enzyme Information
| 1.14.15.4 |
Steroid 11-beta-monooxygenase.
based on mapping to UniProt P15538
A steroid + 2 reduced adrenodoxin + O(2) + 2 H(+) = an 11-beta- hydroxysteroid + 2 oxidized adrenodoxin + H(2)O.
-!- Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone. -!- Formerly EC 1.14.1.6 and EC 1.99.1.7.
|
UniProtKB Entries (1)
| P15538 |
C11B1_HUMAN
Homo sapiens
Cytochrome P450 11B1, mitochondrial
|
PDB Structure
| PDB | 6M7X |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design.
J. Biol. Chem.
|
