CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.170 | Beta Complex |
|
2.170.120 | RNA Polymerase Alpha Subunit; Chain A, domain 2 |
|
2.170.120.12 | DNA-directed RNA polymerase, insert domain |
Domain Context
CATH Clusters
| Superfamily | DNA-directed RNA polymerase, insert domain |
| Functional Family | DNA-directed RNA polymerase subunit alpha |
Enzyme Information
| 2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt P0A7Z4
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
|
UniProtKB Entries (2)
| P0A8V2 |
RPOB_ECOLI
Escherichia coli K-12
DNA-directed RNA polymerase subunit beta
|
| P06223 |
RP54_KLEOX
Klebsiella oxytoca
RNA polymerase sigma-54 factor
|
PDB Structure
| PDB | 6GFW |
| External Links | |
| Method | ELECTRON MICROSCOPY |
| Organism | |
| Primary Citation |
Structures of Bacterial RNA Polymerase Complexes Reveal the Mechanism of DNA Loading and Transcription Initiation.
Mol. Cell
|
