CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.287 | Helix Hairpins |
|
1.10.287.10 | S15/NS1, RNA-binding |
Domain Context
CATH Clusters
| Superfamily | S15/NS1, RNA-binding |
| Functional Family | Bifunctional glutamate/proline--tRNA ligase |
Enzyme Information
| 6.1.1.2 |
Tryptophan--tRNA ligase.
based on mapping to UniProt P23381
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl- tRNA(Trp).
|
UniProtKB Entries (1)
| P23381 |
SYWC_HUMAN
Homo sapiens
Tryptophan--tRNA ligase, cytoplasmic
|
PDB Structure
| PDB | 5UJJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function.
RNA Biol
|
