CATH Domain 4xdyA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.382

Ketol-acid reductoisomerase (NAD(+)).

based on mapping to UniProt Q64BR7

(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) = (2S)-2-hydroxy-2-methyl- 3-oxobutanoate + NADH.

-!- The enzyme, characterized from the bacteria Thermacetogenium phaeum and Desulfococcus oleovorans and from the archaeon Archaeoglobus fulgidus, is specific for NADH (cf. EC 1.1.1.86 and EC 1.1.1.383).

UniProtKB Entries (1)

Q64BR7

ILVC_UNCAG

uncultured archaeon GZfos26G2

Ketol-acid reductoisomerase (NAD(+))

PDB Structure

PDB	4XDY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases. Cahn, J.K., Brinkmann-Chen, S., Spatzal, T., Wiig, J.A., Buller, A.R., Einsle, O., Hu, Y., Ribbe, M.W., Arnold, F.H. Biochem.J.