CATH Domain 4lh5A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.10	Ribonuclease H-like superfamily/Ribonuclease H

Domain Context

CATH Clusters

Superfamily	Ribonuclease H-like superfamily/Ribonuclease H
Functional Family

Enzyme Information

UniProtKB Entries (1)

Q76353_9HIV1

Human immunodeficiency virus 1

Integrase

PDB Structure

PDB	4LH5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage. Le Rouzic, E., Bonnard, D., Chasset, S., Bruneau, J.M., Chevreuil, F., Le Strat, F., Nguyen, J., Beauvoir, R., Amadori, C., Brias, J., Vomscheid, S., Eiler, S., Levy, N., Delelis, O., Deprez, E., Saib, A., Zamborlini, A., Emiliani, S., Ruff, M., Ledoussal, B., Moreau, F., Benarous, R. Retrovirology