CATH Domain 4kprF03

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.390	Enolase-like; domain 1
	3.30.390.30	FAD/NAD-linked reductase, C-terminal dimerisation domain

Superfamily	3.30.390.30
Functional Family	Thioredoxin reductase 1, cytoplasmic

1.8.1.9

Thioredoxin-disulfide reductase.

based on mapping to UniProt O89049

Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.

-!- May be identical to EC 1.8.1.10. -!- Formerly EC 1.6.4.5.

TRXR1_RAT

Rattus norvegicus

Thioredoxin reductase 1, cytoplasmic

PDB	4KPR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Trp114 residue of thioredoxin reductase 1 is an electron relay sensor for oxidative stress Xu, J., Eriksson, S.E., Cebula, M., Sandalova, T., Hedstrom, E., Pader, I., Cheng, Q., Myers, C.R., Nagy, P., Hellman, U., Selivanova, G., Lindqvist, Y., J Arner, E.S. To be Published