CATH Domain 4k48A00

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.740	Isoleucyl-tRNA Synthetase; domain 2
	3.90.740.10	Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain

Superfamily	Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Functional Family

6.1.1.4

Leucine--tRNA ligase.

based on mapping to UniProt B8ZKS5

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

SYL_STRPJ

Streptococcus pneumoniae ATCC 700669

Leucine--tRNA ligase

PDB	4K48
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase Hu, Q.H., Liu, R.J., Fang, Z.P., Zhang, J., Ding, Y.Y., Tan, M., Wang, M., Pan, W., Zhou, H.C., Wang, E.D. Sci Rep