CATH Domain 4k3jA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Hepatocyte growth factor

Enzyme Information

UniProtKB Entries (1)

MET_HUMAN

Homo sapiens

Hepatocyte growth factor receptor

PDB Structure

PDB	4K3J
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent. Merchant, M., Ma, X., Maun, H.R., Zheng, Z., Peng, J., Romero, M., Huang, A., Yang, N.Y., Nishimura, M., Greve, J., Santell, L., Zhang, Y.W., Su, Y., Kaufman, D.W., Billeci, K.L., Mai, E., Moffat, B., Lim, A., Duenas, E.T., Phillips, H.S., Xiang, H., Young, J.C., Vande Woude, G.F., Dennis, M.S., Reilly, D.E., Schwall, R.H., Starovasnik, M.A., Lazarus, R.A., Yansura, D.G. Proc.Natl.Acad.Sci.USA