CATH Domain 3oqvA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.11710	Cyclodipeptide synthase

Domain Context

CATH Clusters

Superfamily	Cyclodipeptide synthase
Functional Family	Cyclo(L-leucyl-L-phenylalanyl) synthase

Enzyme Information

2.3.2.20

Cyclo(L-leucyl-L-phenylalanyl) synthase.

based on mapping to UniProt Q8GED7

L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) = tRNA(Leu) + tRNA(Phe) + cyclo(L-leucyl-L-phenylalanyl).

-!- The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the L-phenylalanine residue. -!- The protein, found in the bacterium Streptomyces noursei, also forms cyclo(L-phenylalanyl-L-phenylalanyl), cyclo(L-methionyl-L- phenylalanyl), cyclo(L-phenylalanyl-L-tyrosyl) and cyclo(L-methionyl- L-tyrosyl).

UniProtKB Entries (1)

Q8GED7

CLPS_STRNR

Streptomyces noursei

Cyclo(L-leucyl-L-phenylalanyl) synthase

PDB Structure

PDB	3OQV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Cyclodipeptide synthases, a family of class-I aminoacyl-tRNA synthetase-like enzymes involved in non-ribosomal peptide synthesis. Sauguet, L., Moutiez, M., Li, Y., Belin, P., Seguin, J., Le Du, M.H., Thai, R., Masson, C., Fonvielle, M., Pernodet, J.L., Charbonnier, J.B., Gondry, M. Nucleic Acids Res.