CATH Domain 3h9rB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.50	Chitinase A; domain 3
	3.10.50.40

Domain Context

CATH Clusters

Superfamily	3.10.50.40
Functional Family	Peptidyl-prolyl cis-trans isomerase FKBP1A

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt P62942

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q04771

ACVR1_HUMAN

Homo sapiens

Activin receptor type-1

PDB Structure

PDB	3H9R
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva. Chaikuad, A., Alfano, I., Kerr, G., Sanvitale, C.E., Boergermann, J.H., Triffitt, J.T., von Delft, F., Knapp, S., Knaus, P., Bullock, A.N. J.Biol.Chem.