CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.11710 | Cyclodipeptide synthase |
Domain Context
CATH Clusters
| Superfamily | Cyclodipeptide synthase |
| Functional Family |
Enzyme Information
| 2.3.2.21 |
Cyclo(L-tyrosyl-L-tyrosyl) synthase.
based on mapping to UniProt P9WPF9
2 L-tyrosyl-tRNA(Tyr) = 2 tRNA(Tyr) + cyclo(L-tyrosyl-L-tyrosyl).
-!- The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-tyrosine residue. -!- The protein, from the bacterium Mycobacterium tuberculosis, also forms small amounts of cyclo(L-tyrosyl-L-phenylalanyl).
|
UniProtKB Entries (1)
| P9WPF9 |
CDTS_MYCTU
Mycobacterium tuberculosis H37Rv
Cyclo(L-tyrosyl-L-tyrosyl) synthase
|
PDB Structure
| PDB | 2X9Q |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The Structure and Mechanism of the Mycobacterium Tuberculosis Cyclodityrosine Synthetase.
Nat.Chem.Biol.
|
