CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.5 | Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
|
1.20.5.460 | Single helix bin |
Domain Context
CATH Clusters
| Superfamily | Single helix bin |
| Functional Family | Malate/L-lactate dehydrogenase |
Enzyme Information
| 1.1.1.237 |
Hydroxyphenylpyruvate reductase.
based on mapping to UniProt P30178
(1) (R)-3-(4-hydroxyphenyl)lactate + NAD(P)(+) = 3-(4-hydroxyphenyl)pyruvate + NAD(P)H. (2) (R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)(+) = 3-(3,4- dihydroxyphenyl)pyruvate + NAD(P)H.
-!- The enzyme participates in the biosynthesis of rosmarinic acid. -!- It belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases, and prefers NADPH to NADH.
|
| 1.1.1.- |
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt P30178
|
UniProtKB Entries (1)
| P30178 |
HCXB_ECOLI
Escherichia coli K-12
Hydroxycarboxylate dehydrogenase B
|
PDB Structure
| PDB | 2G8Y |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The structure of a putative malate/lactate dehydrogenase from E. coli.
To be Published
|
