CATH Domain 2ezvA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.50	OB fold (Dihydrolipoamide Acetyltransferase, E2P)
	2.40.50.610	Type II restriction enzyme SfiI, DNA-recognition domain

Domain Context

CATH Clusters

Superfamily	Type II restriction enzyme SfiI, DNA-recognition domain
Functional Family

Enzyme Information

3.1.21.4

Type II site-specific deoxyribonuclease.

based on mapping to UniProt O52512

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

-!- Large group of enzymes which recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition site. -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/

UniProtKB Entries (1)

O52512

T2S1_STRFI

Streptomyces fimbriatus

Type-2 restriction enzyme SfiI

PDB Structure

PDB	2EZV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A view of consecutive binding events from structures of tetrameric endonuclease SfiI bound to DNA Vanamee, E.S., Viadiu, H., Kucera, R., Dorner, L., Picone, S., Schildkraut, I., Aggarwal, A.K. Embo J.