CATH Domain 2b8nB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1480	glycerate kinase, domain 1
	3.40.1480.10	MOFRL domain

Domain Context

CATH Clusters

Superfamily	MOFRL domain
Functional Family	D-glycerate 2-kinase

Enzyme Information

2.7.1.165

Glycerate 2-kinase.

based on mapping to UniProt Q9X1S1

ATP + D-glycerate = ADP + 2-phospho-D-glycerate.

-!- A key enzyme in the nonphosphorylative Entner-Doudoroff pathway in archaea. -!- In Hyphomicrobium methylovorum GM2 the enzyme is involved in formaldehyde assaimilation I (serine pathway). -!- In Escherichia coli the enzyme is involved in D-glucarate/D-galactarate degradation.

UniProtKB Entries (1)

Q9X1S1

GCK_THEMA

Thermotoga maritima MSB8

D-glycerate 2-kinase

PDB Structure

PDB	2B8N
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2.70 A resolution reveals a new fold Schwarzenbacher, R., McMullan, D., Krishna, S.S., Xu, Q., Miller, M.D., Canaves, J.M., Elsliger, M.A., Floyd, R., Grzechnik, S.K., Jaroszewski, L., Klock, H.E., Koesema, E., Kovarik, J.S., Kreusch, A., Kuhn, P., McPhillips, T.M., Morse, A.T., Quijano, K., Spraggon, G., Stevens, R.C., van den Bedem, H., Wolf, G., Hodgson, K.O., Wooley, J., Deacon, A.M., Godzik, A., Lesley, S.A., Wilson, I.A. Proteins