CATH Domain 2b25B02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.150	Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily	Vaccinia Virus protein VP39
Functional Family	tRNA (Adenine(58)-N(1))-methyltransferase, mitochondrial isoform X4

Enzyme Information

2.1.1.-	Methyltransferases. based on mapping to UniProt Q9BVS5
2.1.1.220	tRNA (adenine(58)-N(1))-methyltransferase. based on mapping to UniProt Q9BVS5 S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA. -!- The enzyme specifically methylates adenine(58) in tRNA. -!- The methylation of A(58) is critical for maintaining the stability of initiator tRNA(Met) in yeast. -!- Formerly EC 2.1.1.36.

UniProtKB Entries (1)

TR61B_HUMAN

Homo sapiens

TRNA (adenine(58)-N(1))-methyltransferase, mitochondrial

PDB Structure

PDB	2B25
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Human putative tRNA(1-methyladenosine)methyltransferase Wu, H., Tempel, W., Dong, A., Zeng, H., Loppnau, P., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Bochkarev, A., Plotnikov, A.N. To be Published