CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.1310 | Replication Protein E1; Chain: A, |
|
3.40.1310.10 |
Domain Context
CATH Clusters
| Superfamily | 3.40.1310.10 |
| Functional Family | Replication protein E1 |
Enzyme Information
| 3.6.4.12 |
DNA helicase.
based on mapping to UniProt P06789
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).
|
UniProtKB Entries (1)
| P06789 |
VE1_HPV18
Human papillomavirus type 18
Replication protein E1
|
PDB Structure
| PDB | 1R9W |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The DNA-binding domain of human papillomavirus type 18 E1. Crystal structure, dimerization, and DNA binding.
J.Biol.Chem.
|
