CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1820 | alpha/beta hydrolase |
Domain Context
CATH Clusters
| Superfamily | alpha/beta hydrolase |
| Functional Family | Carboxylic ester hydrolase |
Enzyme Information
| 3.1.1.1 |
Carboxylesterase.
based on mapping to UniProt P12337
A carboxylic ester + H(2)O = an alcohol + a carboxylate.
-!- Wide specificity; also hydrolyzes vitamin A esters. -!- The enzymes from microsomes also catalyze the reactions of EC 3.1.1.2, EC 3.1.1.5, EC 3.1.1.6, EC 3.1.1.23, EC 3.1.1.28, EC 3.1.2.2, EC 3.5.1.4 and EC 3.5.1.13. -!- Formerly EC 3.1.1.12.
|
UniProtKB Entries (1)
| P12337 |
EST1_RABIT
Oryctolagus cuniculus
Liver carboxylesterase 1
|
PDB Structure
| PDB | 1K4Y |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Spodoptera |
| Primary Citation |
Structural insights into CPT-11 activation by mammalian carboxylesterases.
Nat.Struct.Biol.
|
