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CATH Superfamily 4.10.80.40

succinate dehydrogenase protein domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
succinate dehydrogenase protein domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Succinate dehydrogenase (quinone). [EC: 1.3.5.1]
Succinate + a quinone = fumarate + a quinol.
  • The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria.
  • It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II).
  • In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone.
  • Cf. EC 1.3.5.4.
 244 A0A023YTS3 A0A024QZ30 A0A025CLI4 A0A026V2H0 A0A029I8A0 A0A029IZJ9 A0A069XWI1 A0A070F250 A0A070SQ29 A0A070UK56
(234 more...)
Fumarate reductase (quinol). [EC: 1.3.5.4]
Succinate + a quinone = fumarate + a quinol.
  • The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain.
  • The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, to which it is closely related.
 123 A0A023Z6Q8 A0A025CM19 A0A026V1H2 A0A045H0D0 A0A069XRH4 A0A070FIM1 A0A070UHC1 A0A073G028 A0A074HIB3 A0A080FQ57
(113 more...)