The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
IHF-like DNA-binding proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Integration host factor subunit alpha

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
324 A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) P0A126 (/IDA)
(314 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
324 A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) P0A126 (/IPI)
(314 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
259 A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) P0A6X7 (/IDA)
(249 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
259 A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) P0A6X7 (/IPI)
(249 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
98 P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP)
(88 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
98 P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP)
(88 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
65 P0A126 (/IDA) P0A126 (/IDA) P0A126 (/IDA) P0A126 (/IDA) P0A126 (/IDA) P0A126 (/IDA) P0A126 (/IDA) P0A126 (/IDA) P0A126 (/IDA) P0A126 (/IDA)
(55 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
65 P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP)
(55 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
65 P0A126 (/IPI) P0A126 (/IPI) P0A126 (/IPI) P0A126 (/IPI) P0A126 (/IPI) P0A126 (/IPI) P0A126 (/IPI) P0A126 (/IPI) P0A126 (/IPI) P0A126 (/IPI)
(55 more)

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
217 P0A6X7 (/IDA) P0A6X7 (/IDA) P0A6X7 (/IDA) P0A6X7 (/IDA) P0A6X7 (/IDA) P0A6X7 (/IDA) P0A6X7 (/IDA) P0A6X7 (/IDA) P0A6X7 (/IDA) P0A6X7 (/IDA)
(207 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
217 P0A6X7 (/IEP) P0A6X7 (/IEP) P0A6X7 (/IEP) P0A6X7 (/IEP) P0A6X7 (/IEP) P0A6X7 (/IEP) P0A6X7 (/IEP) P0A6X7 (/IEP) P0A6X7 (/IEP) P0A6X7 (/IEP)
(207 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
217 P0A6X7 (/IMP) P0A6X7 (/IMP) P0A6X7 (/IMP) P0A6X7 (/IMP) P0A6X7 (/IMP) P0A6X7 (/IMP) P0A6X7 (/IMP) P0A6X7 (/IMP) P0A6X7 (/IMP) P0A6X7 (/IMP)
(207 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
33 Q51472 (/IEP) Q51472 (/IEP) Q51472 (/IEP) Q51472 (/IEP) Q51472 (/IEP) Q51472 (/IEP) Q51472 (/IEP) Q51472 (/IEP) Q51472 (/IEP) Q51472 (/IEP)
(23 more)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
324 A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) A5F1W7 (/IDA) P0A126 (/IDA)
(314 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
324 A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) A5F1W7 (/IPI) P0A126 (/IPI)
(314 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
217 P0A6X7 (/IDA) P0A6X7 (/IDA) P0A6X7 (/IDA) P0A6X7 (/IDA) P0A6X7 (/IDA) P0A6X7 (/IDA) P0A6X7 (/IDA) P0A6X7 (/IDA) P0A6X7 (/IDA) P0A6X7 (/IDA)
(207 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
98 P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP) P0A126 (/IMP)
(88 more)