The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Histone-like protein H-NS, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: DNA-binding protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
586 P09120 (/IPI) P09120 (/IPI) P09120 (/IPI) P09120 (/IPI) P09120 (/IPI) P09120 (/IPI) P09120 (/IPI) P09120 (/IPI) P09120 (/IPI) P09120 (/IPI)
(576 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
310 P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI)
(300 more)
Bent DNA binding GO:0003681
Interacting selectively and non-covalently with DNA in a bent conformation.
274 P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA)
(264 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
194 A0A087I6S4 (/IDA) A0A087I6S4 (/IDA) A0A087I6S4 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA)
(184 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
194 A0A087I6S4 (/IPI) A0A087I6S4 (/IPI) A0A087I6S4 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI)
(184 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
194 A0A087I6S4 (/IDA) A0A087I6S4 (/IDA) A0A087I6S4 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA)
(184 more)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
194 A0A087I6S4 (/IPI) A0A087I6S4 (/IPI) A0A087I6S4 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI)
(184 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
136 P0ACG1 (/IDA) P0ACG1 (/IDA) P0ACG1 (/IDA) P0ACG1 (/IDA) P0ACG1 (/IDA) P0ACG1 (/IDA) P0ACG1 (/IDA) P0ACG1 (/IDA) P0ACG1 (/IDA) P0ACG1 (/IDA)
(126 more)
AT DNA binding GO:0003680
Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA).
100 P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA)
(90 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
8 Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS)

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
174 P0ACF8 (/EXP) P0ACF8 (/EXP) P0ACF8 (/EXP) P0ACF8 (/EXP) P0ACF8 (/EXP) P0ACF8 (/EXP) P0ACF8 (/EXP) P0ACF8 (/EXP) P0ACF8 (/EXP) P0ACF8 (/EXP)
(164 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
174 P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA)
(164 more)
Negative regulation of single-species biofilm formation on inanimate substrate GO:1900232
Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation on inanimate substrate.
174 P0ACF8 (/IMP) P0ACF8 (/IMP) P0ACF8 (/IMP) P0ACF8 (/IMP) P0ACF8 (/IMP) P0ACF8 (/IMP) P0ACF8 (/IMP) P0ACF8 (/IMP) P0ACF8 (/IMP) P0ACF8 (/IMP)
(164 more)
Gene silencing GO:0016458
Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression.
100 P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA) P0A1S2 (/IDA)
(90 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
100 P0A1S2 (/IMP) P0A1S2 (/IMP) P0A1S2 (/IMP) P0A1S2 (/IMP) P0A1S2 (/IMP) P0A1S2 (/IMP) P0A1S2 (/IMP) P0A1S2 (/IMP) P0A1S2 (/IMP) P0A1S2 (/IMP)
(90 more)
DNA packaging GO:0006323
Any process in which DNA and associated proteins are formed into a compact, orderly structure.
8 Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS)
Pilus assembly GO:0009297
The assembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
8 Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
8 Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
310 P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA)
(300 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
194 A0A087I6S4 (/IDA) A0A087I6S4 (/IDA) A0A087I6S4 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA) P0ACF8 (/IDA)
(184 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
194 A0A087I6S4 (/IPI) A0A087I6S4 (/IPI) A0A087I6S4 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI) P0ACF8 (/IPI)
(184 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
174 P0ACF8 (/HDA) P0ACF8 (/HDA) P0ACF8 (/HDA) P0ACF8 (/HDA) P0ACF8 (/HDA) P0ACF8 (/HDA) P0ACF8 (/HDA) P0ACF8 (/HDA) P0ACF8 (/HDA) P0ACF8 (/HDA)
(164 more)
Chromosome GO:0005694
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
8 Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS) Q9KSX6 (/ISS)