The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Low-density Lipoprotein Receptor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 44: Basement membrane-specific heparan sulfate proteog...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q04833 (/IPI)
Sterol transporter activity GO:0015248
Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
1 Q04833 (/IMP)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Defasciculation of motor neuron axon GO:0007415
Separation of a motor axon away from a bundle of axons known as a fascicle.
23 A0A023GRW4 (/IMP) E1JJC0 (/IMP) M9NDL5 (/IMP) M9NDM1 (/IMP) M9NE56 (/IMP) M9NE61 (/IMP) M9NES6 (/IMP) M9NET2 (/IMP) M9NFR6 (/IMP) M9NFS1 (/IMP)
(13 more)
Motor neuron axon guidance GO:0008045
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
23 A0A023GRW4 (/IMP) E1JJC0 (/IMP) M9NDL5 (/IMP) M9NDM1 (/IMP) M9NE56 (/IMP) M9NE61 (/IMP) M9NES6 (/IMP) M9NET2 (/IMP) M9NFR6 (/IMP) M9NFS1 (/IMP)
(13 more)
Maintenance of epithelial cell apical/basal polarity GO:0045199
The maintenance of the apicobasal polarity of an epithelial cell.
23 A0A023GRW4 (/IMP) E1JJC0 (/IMP) M9NDL5 (/IMP) M9NDM1 (/IMP) M9NE56 (/IMP) M9NE61 (/IMP) M9NES6 (/IMP) M9NET2 (/IMP) M9NFR6 (/IMP) M9NFS1 (/IMP)
(13 more)
Response to anesthetic GO:0072347
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation.
23 A0A023GRW4 (/IMP) E1JJC0 (/IMP) M9NDL5 (/IMP) M9NDM1 (/IMP) M9NE56 (/IMP) M9NE61 (/IMP) M9NES6 (/IMP) M9NET2 (/IMP) M9NFR6 (/IMP) M9NFS1 (/IMP)
(13 more)
Positive regulation of semaphorin-plexin signaling pathway GO:2001262
Any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway.
23 A0A023GRW4 (/IGI) E1JJC0 (/IGI) M9NDL5 (/IGI) M9NDM1 (/IGI) M9NE56 (/IGI) M9NE61 (/IGI) M9NES6 (/IGI) M9NET2 (/IGI) M9NFR6 (/IGI) M9NFS1 (/IGI)
(13 more)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
4 A0A0R4IZA6 (/IMP) B2RZI0 (/IMP) F1R5K7 (/IMP) F1RCP6 (/IMP)
Endothelial cell proliferation GO:0001935
The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
4 A0A0R4IZA6 (/IMP) B2RZI0 (/IMP) F1R5K7 (/IMP) F1RCP6 (/IMP)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
4 A0A0R4IZA6 (/IMP) B2RZI0 (/IMP) F1R5K7 (/IMP) F1RCP6 (/IMP)
Blood vessel endothelial cell migration GO:0043534
The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis.
4 A0A0R4IZA6 (/IMP) B2RZI0 (/IMP) F1R5K7 (/IMP) F1RCP6 (/IMP)
Regulation of endocytosis GO:0030100
Any process that modulates the frequency, rate or extent of endocytosis.
2 A8JTM7 (/IMP) Q95SN5 (/IMP)
Chitin-based cuticle development GO:0040003
Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster.
2 A8JTM7 (/IMP) Q95SN5 (/IMP)
Regulation of adult chitin-containing cuticle pigmentation GO:0048082
Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism.
2 A8JTM7 (/IMP) Q95SN5 (/IMP)
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 Q04833 (/IMP)
Sterol transport GO:0015918
The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
1 Q04833 (/IMP)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
1 Q04833 (/IGI)
Positive regulation of locomotion GO:0040017
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
1 Q04833 (/IMP)
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
1 Q04833 (/IMP)
Negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037
Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
1 Q9W4Y3 (/IGI)
Ecdysis, collagen and cuticulin-based cuticle GO:0042395
The shedding of the old collagen and cuticulin-based cuticle fragments during the molting cycle. Examples of this process are found in invertebrates.
1 Q04833 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
5 M9NET2 (/ISS) M9NFS1 (/ISS) M9NGK3 (/ISS) Q8MPN3 (/ISS) Q9NEF9 (/ISS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
3 A8JTM7 (/IDA) Q04833 (/IDA) Q95SN5 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 A8JTM7 (/HDA) Q95SN5 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 A8JTM7 (/HDA) Q95SN5 (/HDA)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
1 Q9W4Y3 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q5VYJ5 (/IDA)
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
1 Q04833 (/IDA)