The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
CART, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Cocaine-and amphetamine-regulated transcript prote...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P49192 (/IPI) Q16568 (/IPI)
Neuropeptide hormone activity GO:0005184
The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones.
1 P56388 (/TAS)

There are 47 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular glucose homeostasis GO:0001678
A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.
7 P49192 (/ISS) P56388 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q9BDP9 (/ISS)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
7 P56388 (/ISS) Q16568 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q9BDP9 (/ISS)
Positive regulation of epinephrine secretion GO:0032812
Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine.
7 P49192 (/ISS) P56388 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q9BDP9 (/ISS)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
7 P56388 (/ISS) Q16568 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q9BDP9 (/ISS)
Positive regulation of blood pressure GO:0045777
Any process in which the force of blood traveling through the circulatory system is increased.
7 P49192 (/ISS) P56388 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q9BDP9 (/ISS)
Positive regulation of transmission of nerve impulse GO:0051971
Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
7 P49192 (/ISS) P56388 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q9BDP9 (/ISS)
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
6 Q16568 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q9BDP9 (/ISS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
6 Q16568 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q9BDP9 (/ISS)
Adult feeding behavior GO:0008343
Feeding behavior in a fully developed and mature organism.
6 Q16568 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q9BDP9 (/ISS)
Negative regulation of appetite GO:0032099
Any process that reduces appetite.
6 Q16568 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q9BDP9 (/ISS)
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
2 P49192 (/IDA) P56388 (/IDA)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
2 P49192 (/IDA) P56388 (/IDA)
Adult feeding behavior GO:0008343
Feeding behavior in a fully developed and mature organism.
2 P49192 (/IDA) P56388 (/IDA)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
2 P49192 (/IDA) P56388 (/IDA)
Negative regulation of osteoclast differentiation GO:0045671
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.
2 P56388 (/TAS) Q16568 (/TAS)
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
1 P56388 (/ISO)
Cellular glucose homeostasis GO:0001678
A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.
1 Q16568 (/IDA)
Cellular glucose homeostasis GO:0001678
A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.
1 P56388 (/ISO)
Gastric acid secretion GO:0001696
The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
1 P49192 (/TAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 Q16568 (/TAS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
1 P56388 (/ISO)
Neuropeptide signaling pathway GO:0007218
The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.
1 P56388 (/TAS)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
1 Q16568 (/TAS)
Adult feeding behavior GO:0008343
Feeding behavior in a fully developed and mature organism.
1 P56388 (/ISO)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
1 P56388 (/ISO)
Negative regulation of appetite GO:0032099
Any process that reduces appetite.
1 P49192 (/IDA)
Negative regulation of appetite GO:0032099
Any process that reduces appetite.
1 P56388 (/IMP)
Negative regulation of appetite GO:0032099
Any process that reduces appetite.
1 P56388 (/ISO)
Negative regulation of appetite GO:0032099
Any process that reduces appetite.
1 Q16568 (/TAS)
Positive regulation of epinephrine secretion GO:0032812
Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine.
1 Q16568 (/IDA)
Positive regulation of epinephrine secretion GO:0032812
Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine.
1 P56388 (/ISO)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
1 P49192 (/IDA)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
1 P56388 (/ISO)
Positive regulation of blood pressure GO:0045777
Any process in which the force of blood traveling through the circulatory system is increased.
1 Q16568 (/IDA)
Positive regulation of blood pressure GO:0045777
Any process in which the force of blood traveling through the circulatory system is increased.
1 P56388 (/ISO)
Negative regulation of bone resorption GO:0045779
Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption.
1 P56388 (/IGI)
Negative regulation of bone resorption GO:0045779
Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption.
1 Q16568 (/IMP)
Negative regulation of bone resorption GO:0045779
Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption.
1 P56388 (/ISO)
Regulation of bone remodeling GO:0046850
Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.
1 P56388 (/IMP)
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
1 P49192 (/IDA)
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
1 P56388 (/ISO)
Positive regulation of transmission of nerve impulse GO:0051971
Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
1 Q16568 (/IDA)
Positive regulation of transmission of nerve impulse GO:0051971
Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
1 P56388 (/ISO)
Negative regulation of glucagon secretion GO:0070093
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon.
1 P49192 (/IDA)
Negative regulation of glucagon secretion GO:0070093
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon.
1 P56388 (/ISO)
Somatostatin secretion GO:0070253
The regulated release of somatostatin from secretory granules in the D cells of the pancreas.
1 P49192 (/IDA)
Somatostatin secretion GO:0070253
The regulated release of somatostatin from secretory granules in the D cells of the pancreas.
1 P56388 (/ISO)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
8 P49192 (/ISS) P56388 (/ISS) Q16568 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q68RJ9 (/ISS) Q9BDP9 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 P49192 (/IDA) P56388 (/IDA) Q16568 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P56388 (/ISO)
Secretory granule GO:0030141
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
1 Q16568 (/IDA)
Secretory granule GO:0030141
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
1 P56388 (/ISO)