The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
E3-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Acetyltransferase component of pyruvate dehydrogen...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Dihydrolipoyllysine-residue acetyltransferase activity GO:0004742
Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide.
6 P08461 (/IDA) P10515 (/IDA) P10515 (/IDA) P12695 (/IDA) P12695 (/IDA) P12695 (/IDA)
Dihydrolipoyllysine-residue acetyltransferase activity GO:0004742
Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide.
2 P10515 (/NAS) P10515 (/NAS)
Dihydrolipoyllysine-residue acetyltransferase activity GO:0004742
Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide.
2 P08461 (/TAS) Q8BMF4 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P10515 (/IPI) P10515 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P10515 (/IPI) P10515 (/IPI)
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
1 P08461 (/TAS)
Dihydrolipoyllysine-residue acetyltransferase activity GO:0004742
Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide.
1 Q8BMF4 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q8BMF4 (/ISO)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Acetyl-CoA biosynthetic process from pyruvate GO:0006086
The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
4 P08461 (/IDA) P12695 (/IDA) P12695 (/IDA) P12695 (/IDA)
Acetyl-CoA biosynthetic process from pyruvate GO:0006086
The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
2 B3DIV6 (/IMP) Q804C3 (/IMP)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
2 B3DIV6 (/IMP) Q804C3 (/IMP)
Pyruvate metabolic process GO:0006090
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
2 P10515 (/TAS) P10515 (/TAS)
Detection of light stimulus GO:0009583
The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal.
2 B3DIV6 (/IMP) Q804C3 (/IMP)
Detection of light stimulus involved in visual perception GO:0050908
The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.
2 B3DIV6 (/IMP) Q804C3 (/IMP)
Acetyl-CoA biosynthetic process from pyruvate GO:0006086
The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
1 Q8BMF4 (/ISO)
Sleep GO:0030431
Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.
1 P08461 (/IEP)
Mitochondrial acetyl-CoA biosynthetic process from pyruvate GO:0061732
The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate in the mitochondrion. The process begins with the transport of pyruvate from the cytosol to the mitochondrion where it is subsequently decarboxylated to form acetyl-CoA.
1 Q8BMF4 (/IC)
Mitochondrial acetyl-CoA biosynthetic process from pyruvate GO:0061732
The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate in the mitochondrion. The process begins with the transport of pyruvate from the cytosol to the mitochondrion where it is subsequently decarboxylated to form acetyl-CoA.
1 Q8BMF4 (/ISO)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
7 E9PEJ4 (/IDA) H0YDD4 (/IDA) P08461 (/IDA) P10515 (/IDA) P10515 (/IDA) Q86YI5 (/IDA) Q86YI5 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 P10515 (/HDA) P10515 (/HDA) P12695 (/HDA) P12695 (/HDA) P12695 (/HDA) Q8BMF4 (/HDA)
Mitochondrial pyruvate dehydrogenase complex GO:0005967
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
3 P12695 (/IDA) P12695 (/IDA) P12695 (/IDA)
Pyruvate dehydrogenase complex GO:0045254
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).
3 P08461 (/IDA) P10515 (/IDA) P10515 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 P10515 (/TAS) P10515 (/TAS)
Mitochondrial pyruvate dehydrogenase complex GO:0005967
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
2 P10515 (/NAS) P10515 (/NAS)
Pyruvate dehydrogenase complex GO:0045254
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).
2 P08461 (/TAS) Q8BMF4 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8BMF4 (/ISO)
Mitochondrial pyruvate dehydrogenase complex GO:0005967
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
1 Q8BMF4 (/TAS)
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
1 G8BAA7 (/IDA)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
1 Q8BMF4 (/HDA)
Pyruvate dehydrogenase complex GO:0045254
Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).
1 Q8BMF4 (/ISO)