The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutamyl-tRNA Synthetase; Domain 3
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Glutamine--tRNA ligase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutamine-tRNA ligase activity GO:0004819
Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).
80 P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA)
(70 more)
Glutamine-tRNA ligase activity GO:0004819
Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).
7 Q9KTA6 (/ISS) Q9KTA6 (/ISS) Q9KTA6 (/ISS) Q9KTA6 (/ISS) Q9KTA6 (/ISS) Q9KTA6 (/ISS) Q9KTA6 (/ISS)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
6 P46655 (/HDA) P46655 (/HDA) P46655 (/HDA) P46655 (/HDA) P46655 (/HDA) P46655 (/HDA)
Glutamate-tRNA ligase activity GO:0004818
Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
6 P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P46655 (/IPI) P46655 (/IPI) P46655 (/IPI) P46655 (/IPI) P46655 (/IPI) P46655 (/IPI)
Glutamate-tRNA ligase activity GO:0004818
Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
2 Q8IDK7 (/ISS) Q8IDK7 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 Q8IDK7 (/ISS) Q8IDK7 (/ISS)
Glutamate-tRNA ligase activity GO:0004818
Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
1 P28668 (/TAS)
Proline-tRNA ligase activity GO:0004827
Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).
1 P28668 (/TAS)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutaminyl-tRNA aminoacylation GO:0006425
The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
80 P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA)
(70 more)
Glutaminyl-tRNA aminoacylation GO:0006425
The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
7 Q9KTA6 (/ISS) Q9KTA6 (/ISS) Q9KTA6 (/ISS) Q9KTA6 (/ISS) Q9KTA6 (/ISS) Q9KTA6 (/ISS) Q9KTA6 (/ISS)
Glutamyl-tRNA aminoacylation GO:0006424
The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
6 P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA)
Glutamyl-tRNA aminoacylation GO:0006424
The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
2 Q8IDK7 (/ISS) Q8IDK7 (/ISS)
Glutamyl-tRNA aminoacylation GO:0006424
The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
1 P28668 (/TAS)
Prolyl-tRNA aminoacylation GO:0006433
The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.
1 P28668 (/TAS)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
80 P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA) P00962 (/IDA)
(70 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 P46655 (/HDA) P46655 (/HDA) P46655 (/HDA) P46655 (/HDA) P46655 (/HDA) P46655 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
6 P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA)
Methionyl glutamyl tRNA synthetase complex GO:0017102
A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers.
6 P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA) P46655 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P28668 (/TAS)
Aminoacyl-tRNA synthetase multienzyme complex GO:0017101
A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates.
1 P28668 (/IDA)