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CATH Superfamily 3.90.780.10

5'-Nucleotidase, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
5'-Nucleotidase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
5'-nucleotidase. [EC: 3.1.3.5]
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
  • Wide specificity for 5'-nucleotides.
 70 A0A029IB63 A0A029J209 A0A069XNM1 A0A077ZME3 A0A085RCW9 A0A0E1LYM8 A0A0E1T4W7 A0A0F7Z1K6 A0A0H3BJS5 A0A0K9UYR9
(60 more...)
UDP-sugar diphosphatase. [EC: 3.6.1.45]
UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate.
  • UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities.
  • Thus, this enzyme has a specificity distinct from that of EC 3.6.1.21.
  • Some but not all enzymes of this class also appear to have EC 3.1.3.5 activity.
 42 A0A029IB63 A0A029J209 A0A069XNM1 A0A077ZME3 A0A0E1LYM8 A0A0E1T4W7 A0A140NCM7 A0A170U1E1 A0A192CJE2 A0A1E3MVR3
(32 more...)
2',3'-cyclic-nucleotide 2'-phosphodiesterase. [EC: 3.1.4.16]
Nucleoside 2',3'-cyclic phosphate + H(2)O = nucleoside 3'-phosphate.
  • Also hydrolyzes 3'-nucleoside monophosphates and bis-4-nitrophenyl phosphate, but not 3'-deoxynucleotides.
  • Similar reactions are carried out by EC 3.1.27.3 and EC 3.1.27.5.
 26 A0A085P729 A0A0D6HRH1 A0A0F6BAS0 A0A0F7JD96 A0A0H3NIW5 A0A0K9TKK6 A0A0M0PV00 A0A0T9VE95 A0A2T8QRK9 A0A315GU35
(16 more...)
3'-nucleotidase. [EC: 3.1.3.6]
A 3'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
  • Wide specificity for 3'-nucleotides.
 26 A0A085P729 A0A0D6HRH1 A0A0F6BAS0 A0A0F7JD96 A0A0H3NIW5 A0A0K9TKK6 A0A0M0PV00 A0A0T9VE95 A0A2T8QRK9 A0A315GU35
(16 more...)
Apyrase. [EC: 3.6.1.5]
A nucleoside 5'-triphosphate + 2 H(2)O = a nucleoside 5'-phosphate + 2 phosphate.
  • Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates.
  • They differ from ATPases, which specifically hydrolyze ATP, by hydrolyzing both ATP and ADP.
  • Most of the ecto-ATPases that occur on the cell surface and hydrolyze extracellular nucleotides belong to this enzyme family.
 4 B3A0N5 E0D877 F1JZ10 P50635