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CATH Superfamily 3.90.550.10

Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 146: Tout-velu, isoform B

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase. [EC: 2.4.1.224]
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D- glucosaminyl-proteoglycan = UDP + N-acetyl-alpha-D-glucosaminyl-(1->4)- beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan.
  • Involved in the biosynthesis of heparin and heparan sulfate.
  • Some forms of the enzyme from human (particularly the enzyme complex encoded by the EXT1 and EXT2 genes) act as bifunctional glycosyltransferases, which also have the EC 2.4.1.225 activity required for the synthesis of the heparan sulfate disaccharide repeats.
  • Other human forms of this enzyme (e.g. the product of the EXTL1 gene) have only the 4-alpha-N-acetylglucosaminyltransferase activity.
  • In Caenorhabditis elegans, the product of the rib-2 gene displays the activities of this enzyme as well as EC 2.4.1.223.
 4 A0A0B4KER9 A0A0B4KER9 Q9V730 Q9V730
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase. [EC: 2.4.1.225]
UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D- glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->4)-N-acetyl- alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan.
  • Involved in the biosynthesis of heparin and heparan sulfate.
  • Some forms of the human enzyme (particularly the enzyme complex encoded by the EXT1 and EXT2 genes) act as bifunctional glycosyltransferases, which also have the EC 2.4.1.244 activity required for the synthesis of the heparan sulfate disaccharide repeats.
 4 A0A0B4KER9 A0A0B4KER9 Q9V730 Q9V730