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CATH Superfamily 3.90.400.10

Oligo-1,6-glucosidase; Domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Oligo-1,6-glucosidase; Domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 14 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Oligo-1,6-glucosidase. [EC: 3.2.1.10]
Hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose.
  • This enzyme, like EC 3.2.1.33, can release an alpha-1->6-linked glucose, whereas the shortest chain that can be released by EC 3.2.1.41, EC 3.2.1.142 and EC 3.2.1.68 is maltose.
  • It also hydrolyzes isomaltulose (palatinose), isomaltotriose and panose, but has no action on glycogen or phosphorylase limit dextrin.
  • The enzyme from intestinal mucosa is a single polypeptide chain that also catalyzes the reaction of EC 3.2.1.48.
  • Differs from EC 3.2.1.33 in its preference for short-chain substrates and in its not requiring the 6-glucosylated residue to be at a branch point, i.e. linked at both C-1 and C-4.
 31 A0A162QPD0 A0A164TJS2 A0A164W479 A0A1B2B9Q3 A0A1D8FLI0 A0A1D8FMG0 A0A2X1XFV0 A0A437SA56 E1AFY6 E1AFY7
(21 more...)
Alpha-glucosidase. [EC: 3.2.1.20]
Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
  • Group of enzymes whose specificity is directed mainly toward the exohydrolysis of 1,4-alpha-glucosidic linkages, and that hydrolyze oligosaccharides rapidly, relative to polysaccharides, which are hydrolyzed relatively slowly, or not at all.
  • The intestinal enzyme also hydrolyzes polysaccharides, catalyzing the reactions of EC 3.2.1.3, and, more slowly, hydrolyzes 1,6-alpha-D- glucose links.
 22 A0A0E0U989 A0A0L8VUH9 A0A222H1A7 B3LML3 B5VEP2 C4YN96 E1AFY8 N1PAX0 O16098 O16099
(12 more...)
Alpha-amylase. [EC: 3.2.1.1]
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.
  • Acts on starch, glycogen and related polysaccharides and oligosaccharides in a random manner; reducing groups are liberated in the alpha-configuration.
  • The term 'alpha' relates to the initial anomeric configuration of the free sugar group released and not to the configuration of the linkage hydrolyzed.
 18 A0A045HSE3 A0A0D6J2U4 A0A0H3LBF1 A0A0H3M9U6 A0A0K2HQZ2 A0A109SJW8 A0A109STB9 A0A2U9PZU0 A0A328GXL6 A0R6E0
(8 more...)
Maltose alpha-D-glucosyltransferase. [EC: 5.4.99.16]
Maltose = alpha,alpha-trehalose.
    		 17 A0A045HSE3 A0A0D6J2U4 A0A0H3LBF1 A0A0H3M9U6 A0A0K2HQZ2 A0A109SJW8 A0A109STB9 A0A2U9PZU0 A0A328GXL6 A0R6E0
    (7 more...)
    Cyclomaltodextrinase. [EC: 3.2.1.54]
    Cyclomaltodextrin + H(2)O = linear maltodextrin.
    • Also hydrolyzes linear maltodextrin.
    • Formerly EC 3.2.1.12 and EC 3.2.1.13.
    		 8 A0A358W0P3 B9K7K5 E8UWK6 G4FGM1 O86959 P29964 Q08341 Q9X2F4
    Alpha,alpha-phosphotrehalase. [EC: 3.2.1.93]
    Alpha,alpha-trehalose 6-phosphate + H(2)O = D-glucose + D-glucose 6-phosphate.
      		 6 A0A024L7P1 A0A164UHE3 A0A1B2BAI5 L8ADX8 P28904 P39795
      Sucrose phosphorylase. [EC: 2.4.1.7]
      Sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate.
      • In the forward reaction, arsenate may replace phosphate.
      • In the reverse reaction, various ketoses and L-arabinose may replace D-fructose.
      		 4 A0ZZH6 P10249 P33910 Q59495
      Glucosylglycerate phosphorylase. [EC: 2.4.1.352]
      2-O-(alpha-D-glucopyranosyl)-D-glycerate + phosphate = alpha-D- glucopyranose 1-phosphate + D-glycerate.
      • The enzyme has been characterized from the bacterium Meiothermus silvanus.
      		 4 A0A2S5ZQN0 D7BAR0 G0GBS4 P76041
      4-alpha-glucanotransferase. [EC: 2.4.1.25]
      Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.
      • An enzymic activity of this nature forms part of the mammalian and Saccharomyces cerevisiae glycogen branching system (see EC 3.2.1.33).
      • Formerly EC 2.4.1.3.
      		 3 G4FHS6 O86956 P80099
      Neopullulanase. [EC: 3.2.1.135]
      Hydrolysis of pullulan to panose (6-alpha-D-glucosylmaltose).
      • Cf. EC 3.2.1.41 and EC 3.2.1.57.
      		 3 P38940 Q08751 Q7DI93
      Glucan 1,6-alpha-glucosidase. [EC: 3.2.1.70]
      Hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D- glucans and derived oligosaccharides.
      • Hydrolysis is accompanied by inversion at C-1, so that new reducing ends are released in the beta-configuration.
      • Dextrans and isomaltosaccharides are hydrolyzed, as is isomaltose, but very slowly.
      • The enzyme from some sources also possesses the activity of EC 3.2.1.59.
      		 3 Q54796 Q59905 Q99040
      Amylosucrase. [EC: 2.4.1.4]
      Sucrose + ((1->4)-alpha-D-glucosyl)(n) = D-fructose + ((1->4)-alpha-D- glucosyl)(n+1).
        		 3 E2PEX2 Q84HD6 Q9ZEU2
        Glucan 1,4-alpha-maltohydrolase. [EC: 3.2.1.133]
        Hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains.
        • Acts on starch and related polysaccharides and oligosaccharides.
        • The product is alpha-maltose; cf. EC 3.2.1.2.
        		 2 P32818 Q04977
        Sucrose 6(F)-phosphate phosphorylase. [EC: 2.4.1.329]
        Sucrose 6(F)-phosphate + phosphate = alpha-D-glucopyranose 1-phosphate + beta-D-fructofuranose 6-phosphate.
        • The enzyme, isolated from the thermophilic bacterium Thermoanaerobacterium thermosaccharolyticum, catalyzes the reversible phosphorolysis of sucrose 6(F)-phosphate.
        • It also acts on sucrose with lower activity.
        		 1 D9TT09