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CATH Superfamily 3.90.380.10

Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: Naphthalene 1,2-dioxygenase system, large oxygenas...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Naphthalene 1,2-dioxygenase. [EC: 1.14.12.12]
Naphthalene + NADH + O(2) = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+).
  • Comprises a multicomponent system, containing a reductase that is an iron-sulfur flavoprotein (FAD; EC 1.18.1.3), an iron-sulfur oxygenase, and ferredoxin.
 84 A0A010RDK6 A0A010RDK6 A0A010RDK6 A0A010RDK6 A0A010RDK6 A0A010RDK6 A0A010RDK6 A0A010RDK6 A0A010RDK6 A0A1H4ID50
(74 more...)
2,4-dinitrotoluene dioxygenase. [EC: 1.14.12.24]
2,4-dinitrotoluene + NADH + O(2) = 4-methyl-5-nitrocatechol + nitrite + NAD(+).
  • This enzyme, characterized from the bacterium Burkholderia sp. strain DNT, is a member of the naphthalene family of bacterial Rieske non- heme iron dioxygenases.
  • It comprises a multicomponent system, containing a Rieske [2Fe-2S] ferredoxin, an NADH-dependent flavoprotein reductase (EC 1.18.1.3), and an alpha-3-beta-3 oxygenase.
  • The enzyme forms a cis-dihydroxylated product that spontaneously rearranges to form a catechol with accompanying release of nitrite.
  • It does not act on nitrobenzene.
  • Cf. EC 1.14.12.23.
 1 Q45695