View in Gene3D

CATH Superfamily 3.90.25.10

UDP-galactose 4-epimerase, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
UDP-galactose 4-epimerase, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 15: SDR family oxidoreductase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
NAD(P)H dehydrogenase (quinone). [EC: 1.6.5.2]
NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.
  • The enzyme catalyzes a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone.
  • The animal, but not the plant, form of the enzyme is inhibited by dicoumarol.
  • Formerly EC 1.6.99.2.
 9 A0A1L6B496 A0A1L6B496 A0A1L6B496 P39315 P39315 P39315 S1PCN4 S1PCN4 S1PCN4
Festuclavine dehydrogenase. [EC: 1.5.1.44]
Festuclavine + NAD(+) = 6,8-dimethyl-6,7-didehydroergoline + NADH.
  • The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family.
  • The reaction proceeds in vivo in the opposite direction to the one shown here.
 4 B0XW07 B0XW07 Q4WZ69 Q4WZ69
Agroclavine dehydrogenase. [EC: 1.5.1.46]
Agroclavine + NADP(+) = 6,8-dimethyl-6,7,8,9-tetradehydroergoline + NADPH.
  • The enzyme participates in the biosynthesis of ergotamine, an ergot alkaloid produced by some fungi of the Clavicipitaceae family.
  • The reaction is catalyzed in the opposite direction to that shown.
  • The substrate for the enzyme is an iminium intermediate that is formed spontaneously from chanoclavine-I aldehyde in the presence of glutathione.
 2 M1WEN5 P0CT21