The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
UDP-galactose 4-epimerase, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: UDP-glucose 4-epimerase GalE

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
UDP-glucose 4-epimerase activity GO:0003978
Catalysis of the reaction: UDP-glucose = UDP-galactose.
82 C8VAU8 (/IDA) E8MF10 (/IDA) E8MF10 (/IDA) E8MF10 (/IDA) E8MF10 (/IDA) E8MF10 (/IDA) E8MF10 (/IDA) E8MF10 (/IDA) E8MF10 (/IDA) E8MF10 (/IDA)
(72 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
51 P09147 (/IPI) P09147 (/IPI) P09147 (/IPI) P09147 (/IPI) P09147 (/IPI) P09147 (/IPI) P09147 (/IPI) P09147 (/IPI) P09147 (/IPI) P09147 (/IPI)
(41 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
49 P09147 (/IPI) P09147 (/IPI) P09147 (/IPI) P09147 (/IPI) P09147 (/IPI) P09147 (/IPI) P09147 (/IPI) P09147 (/IPI) P09147 (/IPI) P09147 (/IPI)
(39 more)
Racemase and epimerase activity, acting on carbohydrates and derivatives GO:0016857
Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule.
49 P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA)
(39 more)
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
49 P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA)
(39 more)
UDP-glucose 4-epimerase activity GO:0003978
Catalysis of the reaction: UDP-glucose = UDP-galactose.
8 A0A0F7R8T6 (/ISS) A0A0F7R8T6 (/ISS) Q9KLH0 (/ISS) Q9KLH0 (/ISS) Q9KLH0 (/ISS) Q9KLH0 (/ISS) Q9KLH0 (/ISS) Q9KLH0 (/ISS)
UDP-glucose 4-epimerase activity GO:0003978
Catalysis of the reaction: UDP-glucose = UDP-galactose.
6 Q4WV46 (/IMP) Q4WV46 (/IMP) Q4WV46 (/IMP) Q564Q1 (/IMP) Q9W0P5 (/IMP) Q9W0P5 (/IMP)
UDP-arabinose 4-epimerase activity GO:0050373
Catalysis of the reaction: UDP-L-arabinose = UDP-alpha-D-xylose.
5 B0M3E8 (/IDA) Q42605 (/IDA) Q42605 (/IDA) Q8LDN8 (/IDA) Q8LDN8 (/IDA)
UDP-N-acetylglucosamine 4-epimerase activity GO:0003974
Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine.
4 Q4WX18 (/IDA) Q4WX18 (/IDA) Q4WX18 (/IDA) Q4WX18 (/IDA)
UDP-N-acetylglucosamine 4-epimerase activity GO:0003974
Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine.
3 Q564Q1 (/IMP) Q9W0P5 (/IMP) Q9W0P5 (/IMP)
UDP-glucose 4-epimerase activity GO:0003978
Catalysis of the reaction: UDP-glucose = UDP-galactose.
3 C8VAU8 (/RCA) Q5B929 (/RCA) Q5B929 (/RCA)
UDP-glucose 4-epimerase activity GO:0003978
Catalysis of the reaction: UDP-glucose = UDP-galactose.
2 Q9C7W7 (/TAS) Q9C7W7 (/TAS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q14376 (/IPI) Q14376 (/IPI)
UDP-glucose 4-epimerase activity GO:0003978
Catalysis of the reaction: UDP-glucose = UDP-galactose.
1 A0A1D8PCN0 (/IGI)
UDP-glucose 4-epimerase activity GO:0003978
Catalysis of the reaction: UDP-glucose = UDP-galactose.
1 Q8R059 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q8R059 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q8R059 (/ISO)

There are 43 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Galactose metabolic process GO:0006012
The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
61 C8VAU8 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP)
(51 more)
Galactose metabolic process GO:0006012
The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
50 P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA)
(40 more)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
49 P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP)
(39 more)
Colanic acid biosynthetic process GO:0009242
The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide.
49 P09147 (/IEP) P09147 (/IEP) P09147 (/IEP) P09147 (/IEP) P09147 (/IEP) P09147 (/IEP) P09147 (/IEP) P09147 (/IEP) P09147 (/IEP) P09147 (/IEP)
(39 more)
Colanic acid biosynthetic process GO:0009242
The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide.
49 P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP)
(39 more)
Galactose catabolic process via UDP-galactose GO:0033499
The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose.
49 P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP) P09147 (/IMP)
(39 more)
Carbohydrate metabolic process GO:0005975
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
14 E8MF10 (/IDA) E8MF10 (/IDA) E8MF10 (/IDA) E8MF10 (/IDA) E8MF10 (/IDA) E8MF10 (/IDA) E8MF10 (/IDA) E8MF10 (/IDA) E8MF10 (/IDA) E8MF10 (/IDA)
(4 more)
Galactose metabolic process GO:0006012
The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
8 A0A0F7R8T6 (/ISS) A0A0F7R8T6 (/ISS) Q9KLH0 (/ISS) Q9KLH0 (/ISS) Q9KLH0 (/ISS) Q9KLH0 (/ISS) Q9KLH0 (/ISS) Q9KLH0 (/ISS)
Protein galactosylation GO:0042125
The addition of a galactose molecule to a protein amino acid.
4 Q4WV46 (/IMP) Q4WV46 (/IMP) Q4WV46 (/IMP) Q9HDU3 (/IMP)
Galactose metabolic process GO:0006012
The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
3 C8VAU8 (/RCA) Q5B929 (/RCA) Q5B929 (/RCA)
Cell wall biogenesis GO:0042546
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall. Includes biosynthesis of constituent macromolecules, such as proteins and polysaccharides, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. A cell wall is the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
3 Q9C7W7 (/IMP) Q9C7W7 (/IMP) Q9T0A7 (/IMP)
Pollen development GO:0009555
The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
2 Q8LDN8 (/IMP) Q8LDN8 (/IMP)
Plant-type cell wall biogenesis GO:0009832
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellulose and pectin-containing cell wall. An example of this is found in Arabidopsis thaliana.
2 Q9C7W7 (/TAS) Q9C7W7 (/TAS)
Xyloglucan biosynthetic process GO:0009969
The chemical reactions and pathways resulting in the formation of xyloglucan, the cross-linking glycan composed of (1->4)-beta-D glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants.
2 Q9C7W7 (/IMP) Q9C7W7 (/IMP)
Root epidermal cell differentiation GO:0010053
The process in which a relatively unspecialized cell in the root epidermis acquires the specialized features of a trichoblast or atrichoblast.
2 Q9C7W7 (/IMP) Q9C7W7 (/IMP)
Galactose catabolic process GO:0019388
The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose.
2 Q14376 (/IDA) Q14376 (/IDA)
Galactose catabolic process GO:0019388
The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose.
2 Q14376 (/TAS) Q14376 (/TAS)
Larval lymph gland hemopoiesis GO:0035167
The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages.
2 Q9W0P5 (/IMP) Q9W0P5 (/IMP)
Invasive growth in response to glucose limitation GO:0001403
A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae.
1 A0A1D8PCN0 (/IMP)
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 Q564Q1 (/IMP)
Galactose metabolic process GO:0006012
The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
1 Q6A1A4 (/IC)
Fungal-type cell wall biogenesis GO:0009272
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin.
1 A0A1D8PCN0 (/IMP)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
1 Q564Q1 (/IMP)
Galactose catabolic process GO:0019388
The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose.
1 A0A1D8PCN0 (/IEP)
Galactose catabolic process GO:0019388
The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose.
1 A0A1D8PCN0 (/IGI)
Galactose catabolic process GO:0019388
The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose.
1 A0A1D8PCN0 (/IMP)
Galactose catabolic process GO:0019388
The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose.
1 Q8R059 (/ISO)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
1 A0A1D8PCN0 (/IMP)
Galactose catabolic process via UDP-galactose GO:0033499
The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose.
1 Q8R059 (/IC)
Galactose catabolic process via UDP-galactose GO:0033499
The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose.
1 Q9Y7X5 (/ISS)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 A0A1D8PCN0 (/IMP)
Gonad morphogenesis GO:0035262
The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.
1 Q564Q1 (/IMP)
Positive regulation of vulval development GO:0040026
Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
1 Q564Q1 (/IMP)
Cellular response to glucose starvation GO:0042149
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
1 A0A1D8PCN0 (/IMP)
Cuticle development GO:0042335
The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss.
1 Q564Q1 (/IGI)
Cuticle development GO:0042335
The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss.
1 Q564Q1 (/IMP)
Filamentous growth of a population of unicellular organisms GO:0044182
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
1 A0A1D8PCN0 (/IMP)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
1 Q564Q1 (/IMP)
Negative regulation of flocculation GO:0060257
Any process that decreases the rate, frequency or extent of the non-sexual aggregation of single-celled organisms.
1 A0A1D8PCN0 (/IMP)
Glycolytic process from galactose GO:0061623
The chemical reactions and pathways resulting in the breakdown of galactose into pyruvate, with the concomitant production of a small amount of ATP.
1 Q8R059 (/IC)
Negative regulation of endoplasmic reticulum unfolded protein response GO:1900102
Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response.
1 Q564Q1 (/IMP)
Negative regulation of filamentous growth of a population of unicellular organisms GO:1900429
Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms.
1 A0A1D8PCN0 (/IMP)
Regulation of distal tip cell migration GO:1903354
Any process that modulates the frequency, rate or extent of distal tip cell migration.
1 Q564Q1 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
52 P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA)
(42 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
50 C8VAU8 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA) P09147 (/IDA)
(40 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
49 P09147 (/HDA) P09147 (/HDA) P09147 (/HDA) P09147 (/HDA) P09147 (/HDA) P09147 (/HDA) P09147 (/HDA) P09147 (/HDA) P09147 (/HDA) P09147 (/HDA)
(39 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q14376 (/TAS) Q14376 (/TAS) Q42605 (/TAS) Q42605 (/TAS)
Golgi stack GO:0005795
The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.
2 Q9C7W7 (/IDA) Q9C7W7 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q42605 (/IDA) Q42605 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9Y7X5 (/ISO)