The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Creatinase/methionine aminopeptidase superfamily
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: Proliferation-associated 2G4, b

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 Q6AYD3 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
8 Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
8 Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
8 Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
8 Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI) Q9UQ80 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 P50580 (/ISO) P50580 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 P50580 (/ISO) P50580 (/ISO)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
2 P50580 (/ISO) P50580 (/ISO)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
10 P50580 (/ISS) P50580 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS)
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
10 P50580 (/ISS) P50580 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS) Q9UQ80 (/ISS)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
8 Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
8 Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P50580 (/ISO) P50580 (/ISO)
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
2 P50580 (/ISO) P50580 (/ISO)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 P50580 (/ISO) P50580 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q6AYD3 (/IDA)
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
1 Q6AYD3 (/IDA)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
9 Q6AYD3 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 Q6AYD3 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
8 Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA) Q9UQ80 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
8 Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA)
Azurophil granule lumen GO:0035578
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
8 Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS) Q9UQ80 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
8 Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA) Q9UQ80 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P50580 (/ISO) P50580 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 P50580 (/ISO) P50580 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 P50580 (/ISS) P50580 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P50580 (/ISO) P50580 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P50580 (/ISS) P50580 (/ISS)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
2 P50580 (/ISO) P50580 (/ISO)