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CATH Superfamily 3.90.180.10

Medium-chain alcohol dehydrogenases, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Medium-chain alcohol dehydrogenases, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: S-(hydroxymethyl)glutathione dehydrogenase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Alcohol dehydrogenase. [EC: 1.1.1.1]
(1) A primary alcohol + NAD(+) = an aldehyde + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
  • Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol.
  • The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
 10566 A0A024RDI5 A0A024RDI5 A0A024RDI5 A0A026V5I4 A0A026V5I4 A0A026V5I4 A0A026V5I4 A0A026V5I4 A0A026V5I4 A0A026V5I4
(10556 more...)
S-(hydroxymethyl)glutathione dehydrogenase. [EC: 1.1.1.284]
S-(hydroxymethyl)glutathione + NAD(P)(+) = S-formylglutathione + NAD(P)H.
  • The substrate, S-(hydroxymethyl)glutathione, forms spontaneously from glutathione and formaldehyde; its rate of formation is increased in some bacteria by the presence of EC 4.4.1.22.
  • Forms part of the pathway that detoxifies formaldehyde, since the product is hydrolyzed by EC 3.1.2.12.
  • Also specifically reduces S-nitrosylglutathione.
  • Formerly EC 1.2.1.1.
 10509 A0A026V5I4 A0A026V5I4 A0A026V5I4 A0A026V5I4 A0A026V5I4 A0A026V5I4 A0A026V5I4 A0A026V5I4 A0A026V5I4 A0A026V5I4
(10499 more...)
Octanol dehydrogenase. [EC: 1.1.1.73]
1-octanol + NAD(+) = 1-octanal + NADH.
  • Acts, less rapidly, on other long-chain alcohols.
 1 P46415