The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Chloride channel protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Voltage-gated chloride channel activity GO:0005247
Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
13 P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS)
(3 more)
Chloride channel activity GO:0005254
Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
13 P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA)
(3 more)
Antiporter activity GO:0015297
Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).
13 P51793 (/IMP) P51793 (/IMP) P51793 (/IMP) P51793 (/IMP) P51793 (/IMP) P51793 (/IMP) P51793 (/IMP) P51793 (/IMP) P51793 (/IMP) P51793 (/IMP)
(3 more)
Chloride channel activity GO:0005254
Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
5 P51795 (/TAS) P51795 (/TAS) P51795 (/TAS) P51795 (/TAS) P51795 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P51795 (/IPI) P51795 (/IPI) P51795 (/IPI) P51795 (/IPI) P51795 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
5 P51795 (/IPI) P51795 (/IPI) P51795 (/IPI) P51795 (/IPI) P51795 (/IPI)
Chloride channel activity GO:0005254
Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
3 Q8IQN2 (/ISS) Q8MQK2 (/ISS) Q9VUY1 (/ISS)
Chloride transmembrane transporter activity GO:0015108
Enables the transfer of chloride ions from one side of a membrane to the other.
3 Q8IQN2 (/IMP) Q8MQK2 (/IMP) Q9VUY1 (/IMP)
Antiporter activity GO:0015297
Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).
2 P51794 (/ISS) Q61418 (/ISS)
Voltage-gated chloride channel activity GO:0005247
Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
1 P51796 (/IDA)
Voltage-gated chloride channel activity GO:0005247
Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
1 Q9WVD4 (/ISO)
Chloride channel activity GO:0005254
Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
1 Q9WVD4 (/ISO)
Antiporter activity GO:0015297
Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).
1 Q61418 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q9WVD4 (/ISO)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
18 P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS)
(8 more)
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
14 P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA)
(4 more)
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
13 P51793 (/IMP) P51793 (/IMP) P51793 (/IMP) P51793 (/IMP) P51793 (/IMP) P51793 (/IMP) P51793 (/IMP) P51793 (/IMP) P51793 (/IMP) P51793 (/IMP)
(3 more)
Excretion GO:0007588
The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
5 P51795 (/TAS) P51795 (/TAS) P51795 (/TAS) P51795 (/TAS) P51795 (/TAS)
Renal system process GO:0003014
A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).
3 Q8IQN2 (/IEP) Q8MQK2 (/IEP) Q9VUY1 (/IEP)
Endosomal lumen acidification GO:0048388
Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion.
3 Q8IQN2 (/IMP) Q8MQK2 (/IMP) Q9VUY1 (/IMP)
Chloride transmembrane transport GO:1902476
The process in which chloride is transported across a membrane.
3 Q8IQN2 (/IMP) Q8MQK2 (/IMP) Q9VUY1 (/IMP)
Chloride transmembrane transport GO:1902476
The process in which chloride is transported across a membrane.
3 Q8IQN2 (/ISS) Q8MQK2 (/ISS) Q9VUY1 (/ISS)
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q61418 (/ISO) Q9WVD4 (/ISO)
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P51794 (/ISS) Q61418 (/ISS)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
1 Q9WVD4 (/IMP)

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
18 P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS) P51793 (/TAS)
(8 more)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
13 P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA) P51793 (/IDA)
(3 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
6 P51795 (/IDA) P51795 (/IDA) P51795 (/IDA) P51795 (/IDA) P51795 (/IDA) P51796 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
6 P51795 (/IDA) P51795 (/IDA) P51795 (/IDA) P51795 (/IDA) P51795 (/IDA) Q9WVD4 (/IDA)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
5 P51795 (/HDA) P51795 (/HDA) P51795 (/HDA) P51795 (/HDA) P51795 (/HDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
5 P51795 (/IDA) P51795 (/IDA) P51795 (/IDA) P51795 (/IDA) P51795 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P51795 (/IDA) P51795 (/IDA) P51795 (/IDA) P51795 (/IDA) P51795 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P51795 (/IDA) P51795 (/IDA) P51795 (/IDA) P51795 (/IDA) P51795 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
5 P51795 (/TAS) P51795 (/TAS) P51795 (/TAS) P51795 (/TAS) P51795 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 P51795 (/HDA) P51795 (/HDA) P51795 (/HDA) P51795 (/HDA) P51795 (/HDA)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
3 Q8IQN2 (/IDA) Q8MQK2 (/IDA) Q9VUY1 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 Q8IQN2 (/ISS) Q8MQK2 (/ISS) Q9VUY1 (/ISS)
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
3 Q8IQN2 (/IDA) Q8MQK2 (/IDA) Q9VUY1 (/IDA)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
2 P51796 (/IDA) Q9WVD4 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
2 P51794 (/ISS) Q61418 (/ISS)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 Q9WVD4 (/ISO)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q61418 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q9WVD4 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9WVD4 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9WVD4 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9WVD4 (/ISO)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 Q9WVD4 (/ISO)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 P51796 (/ISS)