The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
DNA Methylase, subunit A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: Methyltransferase 2, isoform C

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA (cytosine-5-)-methyltransferase activity GO:0003886
Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
3 Q8MSZ1 (/IDA) Q9U6H7 (/IDA) Q9VKB3 (/IDA)
DNA (cytosine-5-)-methyltransferase activity GO:0003886
Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.
3 Q8MSZ1 (/ISS) Q9U6H7 (/ISS) Q9VKB3 (/ISS)
Methyltransferase activity GO:0008168
Catalysis of the transfer of a methyl group to an acceptor molecule.
3 Q8MSZ1 (/ISS) Q9U6H7 (/ISS) Q9VKB3 (/ISS)
TRNA methyltransferase activity GO:0008175
Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule.
3 Q8MSZ1 (/IMP) Q9U6H7 (/IMP) Q9VKB3 (/IMP)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Telomere maintenance GO:0000723
Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
3 Q8MSZ1 (/IMP) Q9U6H7 (/IMP) Q9VKB3 (/IMP)
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
3 Q8MSZ1 (/IMP) Q9U6H7 (/IMP) Q9VKB3 (/IMP)
DNA methylation GO:0006306
The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.
3 Q8MSZ1 (/IDA) Q9U6H7 (/IDA) Q9VKB3 (/IDA)
DNA methylation GO:0006306
The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.
3 Q8MSZ1 (/ISS) Q9U6H7 (/ISS) Q9VKB3 (/ISS)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
3 Q8MSZ1 (/IMP) Q9U6H7 (/IMP) Q9VKB3 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
3 Q8MSZ1 (/IMP) Q9U6H7 (/IMP) Q9VKB3 (/IMP)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
3 Q8MSZ1 (/IMP) Q9U6H7 (/IMP) Q9VKB3 (/IMP)
Gene silencing GO:0016458
Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression.
3 Q8MSZ1 (/IMP) Q9U6H7 (/IMP) Q9VKB3 (/IMP)
TRNA methylation GO:0030488
The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.
3 Q8MSZ1 (/IMP) Q9U6H7 (/IMP) Q9VKB3 (/IMP)
DNA methylation involved in embryo development GO:0043045
The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression.
3 Q8MSZ1 (/IMP) Q9U6H7 (/IMP) Q9VKB3 (/IMP)
Positive regulation of innate immune response GO:0045089
Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
3 Q8MSZ1 (/IMP) Q9U6H7 (/IMP) Q9VKB3 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q8MSZ1 (/IDA) Q9U6H7 (/IDA) Q9VKB3 (/IDA)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
3 Q8MSZ1 (/IDA) Q9U6H7 (/IDA) Q9VKB3 (/IDA)
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
3 Q8MSZ1 (/IDA) Q9U6H7 (/IDA) Q9VKB3 (/IDA)