CATH Superfamily 3.90.1170.50
Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
".
FunFam 1: Aldehyde oxidase 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 30 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Molybdopterin cofactor binding GO:0043546
Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.
|
21 |
C4NYZ3 (/ISS)
G3X982 (/ISS)
H9TB17 (/ISS)
H9TB18 (/ISS)
H9TB19 (/ISS)
O54754 (/ISS)
P08793 (/ISS)
P10351 (/ISS)
P22811 (/ISS)
P48034 (/ISS)
(11 more) |
|
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
|
21 |
C4NYZ3 (/ISS)
G3X982 (/ISS)
H9TB17 (/ISS)
H9TB18 (/ISS)
H9TB19 (/ISS)
O54754 (/ISS)
P08793 (/ISS)
P10351 (/ISS)
P22811 (/ISS)
P48034 (/ISS)
(11 more) |
|
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
|
21 |
C4NYZ3 (/ISS)
G3X982 (/ISS)
H9TB17 (/ISS)
H9TB18 (/ISS)
H9TB19 (/ISS)
O54754 (/ISS)
P08793 (/ISS)
P10351 (/ISS)
P22811 (/ISS)
P48034 (/ISS)
(11 more) |
|
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
|
14 |
C4NYZ3 (/ISS)
G3X982 (/ISS)
H9TB17 (/ISS)
H9TB18 (/ISS)
H9TB19 (/ISS)
O54754 (/ISS)
P48034 (/ISS)
P80456 (/ISS)
Q3TYQ9 (/ISS)
Q5QE78 (/ISS)
(4 more) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
13 |
C4NYZ3 (/ISS)
G3X982 (/ISS)
H9TB17 (/ISS)
H9TB18 (/ISS)
H9TB19 (/ISS)
P48034 (/ISS)
P80456 (/ISS)
Q3TYQ9 (/ISS)
Q5QE78 (/ISS)
Q5QE79 (/ISS)
(3 more) |
|
Retinal oxidase activity GO:0050250
Catalysis of the reaction: retinal + O2 + H2O = retinoate + H2O2.
|
13 |
C4NYZ3 (/ISS)
G3X982 (/ISS)
H9TB17 (/ISS)
H9TB18 (/ISS)
H9TB19 (/ISS)
P48034 (/ISS)
P80456 (/ISS)
Q3TYQ9 (/ISS)
Q5QE78 (/ISS)
Q5QE79 (/ISS)
(3 more) |
|
Aldehyde oxidase activity GO:0004031
Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.
|
11 |
C4NYZ3 (/ISS)
H9TB17 (/ISS)
H9TB18 (/ISS)
H9TB19 (/ISS)
P48034 (/ISS)
P80456 (/ISS)
Q3TYQ9 (/ISS)
Q5QE78 (/ISS)
Q5QE79 (/ISS)
Q5QE80 (/ISS)
(1 more) |
|
Xanthine dehydrogenase activity GO:0004854
Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.
|
6 | P08793 (/ISS) P10351 (/ISS) P22811 (/ISS) P91711 (/ISS) Q12553 (/ISS) Q54FB7 (/ISS) |
|
Aldehyde oxidase activity GO:0004031
Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.
|
5 | G3X982 (/IDA) O54754 (/IDA) Q06278 (/IDA) Q9ESH4 (/IDA) Q9Z0U5 (/IDA) |
|
Xanthine dehydrogenase activity GO:0004854
Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.
|
3 | Q12553 (/IDA) Q8GUQ8 (/IDA) R4ZGN4 (/IDA) |
|
Electron transfer activity GO:0009055
Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
|
3 | G3X982 (/IDA) O54754 (/IDA) Q9ESH4 (/IDA) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
3 | O54754 (/IDA) Q06278 (/IDA) R4ZGN4 (/IDA) |
|
Xanthine dehydrogenase activity GO:0004854
Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.
|
2 | P10351 (/IMP) Q12553 (/IMP) |
|
Electron transfer activity GO:0009055
Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
|
2 | G3X982 (/ISA) Q3TYQ9 (/ISA) |
|
Molybdenum ion binding GO:0030151
Interacting selectively and non-covalently with molybdenum (Mo) ions.
|
2 | G3X982 (/IDA) Q9ESH4 (/IDA) |
|
Aldehyde oxidase activity GO:0004031
Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.
|
1 | Q3TYQ9 (/ISA) |
|
Aldehyde oxidase activity GO:0004031
Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.
|
1 | O54754 (/ISO) |
|
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
|
1 | Q06278 (/IDA) |
|
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
|
1 | O54754 (/ISO) |
|
Molybdenum ion binding GO:0030151
Interacting selectively and non-covalently with molybdenum (Mo) ions.
|
1 | Q3TYQ9 (/ISA) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q06278 (/IPI) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | O54754 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | O54754 (/ISO) |
|
Molybdopterin cofactor binding GO:0043546
Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.
|
1 | Q06278 (/IDA) |
|
Molybdopterin cofactor binding GO:0043546
Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.
|
1 | O54754 (/ISO) |
|
Retinal oxidase activity GO:0050250
Catalysis of the reaction: retinal + O2 + H2O = retinoate + H2O2.
|
1 | O54754 (/IDA) |
|
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
|
1 | Q06278 (/IDA) |
|
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
|
1 | O54754 (/ISO) |
|
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
|
1 | Q06278 (/IDA) |
|
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
|
1 | O54754 (/ISO) |
There are 33 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Drug metabolic process GO:0017144
The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.
|
14 |
C4NYZ3 (/ISS)
G3X982 (/ISS)
H9TB17 (/ISS)
H9TB18 (/ISS)
H9TB19 (/ISS)
O54754 (/ISS)
P48034 (/ISS)
P80456 (/ISS)
Q3TYQ9 (/ISS)
Q5QE78 (/ISS)
(4 more) |
|
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
11 |
C4NYZ3 (/ISS)
H9TB17 (/ISS)
H9TB18 (/ISS)
H9TB19 (/ISS)
P48034 (/ISS)
P80456 (/ISS)
Q3TYQ9 (/ISS)
Q5QE78 (/ISS)
Q5QE79 (/ISS)
Q5QE80 (/ISS)
(1 more) |
|
Xanthine catabolic process GO:0009115
The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.
|
6 | P08793 (/ISS) P10351 (/ISS) P22811 (/ISS) P91711 (/ISS) Q12553 (/ISS) Q54FB7 (/ISS) |
|
Purine nucleobase catabolic process GO:0006145
The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
|
2 | Q12553 (/IDA) R4ZGN4 (/IDA) |
|
Purine nucleobase catabolic process GO:0006145
The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
|
2 | Q12553 (/IMP) Q8GUQ8 (/IMP) |
|
Drug metabolic process GO:0017144
The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.
|
2 | O54754 (/IDA) Q06278 (/IDA) |
|
Xanthine metabolic process GO:0046110
The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.
|
2 | F4JLI5 (/IMP) Q8GUQ8 (/IMP) |
|
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
|
1 | Q8GUQ8 (/IMP) |
|
Purine nucleobase metabolic process GO:0006144
The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
|
1 | P10351 (/IMP) |
|
Purine nucleobase catabolic process GO:0006145
The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
|
1 | Q8GUQ8 (/TAS) |
|
Guanine catabolic process GO:0006147
The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important.
|
1 | R4ZGN4 (/IDA) |
|
Hypoxanthine oxidation GO:0006150
The chemical reactions and pathways resulting in the breakdown of hypoxanthine to xanthine and thence to uric acid.
|
1 | R4ZGN4 (/IDA) |
|
Xanthine oxidation GO:0006151
The oxidation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.
|
1 | R4ZGN4 (/IDA) |
|
Pyrimidine nucleobase metabolic process GO:0006206
The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
|
1 | P10351 (/IMP) |
|
Arginine metabolic process GO:0006525
The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
|
1 | P10351 (/IMP) |
|
Tryptophan metabolic process GO:0006568
The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
|
1 | P10351 (/IMP) |
|
Glycerophospholipid metabolic process GO:0006650
The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
|
1 | P10351 (/IMP) |
|
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
|
1 | Q9Z0U5 (/TAS) |
|
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
|
1 | P10351 (/IMP) |
|
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
|
1 | Q8GUQ8 (/IMP) |
|
Drug metabolic process GO:0017144
The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.
|
1 | O54754 (/ISO) |
|
Drug metabolic process GO:0017144
The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.
|
1 | Q9Z0U5 (/TAS) |
|
Superoxide anion generation GO:0042554
The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways.
|
1 | Q8GUQ8 (/IMP) |
|
Vitamin B6 metabolic process GO:0042816
The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.
|
1 | Q06278 (/TAS) |
|
Compound eye pigmentation GO:0048072
Establishment of a pattern of pigment in the compound eye.
|
1 | P10351 (/TAS) |
|
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
1 | Q06278 (/IDA) |
|
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
1 | O54754 (/ISO) |
|
Cellular response to ammonium ion GO:0071242
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus.
|
1 | R4ZGN4 (/IEP) |
|
Cellular response to nitrate GO:0071249
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus.
|
1 | R4ZGN4 (/IEP) |
|
Cellular response to cadmium ion GO:0071276
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
|
1 | R4ZGN4 (/IDA) |
|
Cellular response to copper ion GO:0071280
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
|
1 | R4ZGN4 (/IDA) |
|
Cellular response to iron ion GO:0071281
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
|
1 | R4ZGN4 (/IDA) |
|
Cellular response to zinc ion GO:0071294
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
|
1 | R4ZGN4 (/IDA) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
14 |
C4NYZ3 (/ISS)
G3X982 (/ISS)
H9TB17 (/ISS)
H9TB18 (/ISS)
H9TB19 (/ISS)
O54754 (/ISS)
P48034 (/ISS)
P80456 (/ISS)
Q3TYQ9 (/ISS)
Q5QE78 (/ISS)
(4 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | M1ZMM0 (/IDA) Q1LW04 (/IDA) R4ZGN4 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | O54754 (/IDA) Q06278 (/IDA) Q8GUQ8 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q06278 (/TAS) Q9Z0U5 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O54754 (/ISO) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q06278 (/HDA) |