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CATH Superfamily 3.90.1170.30

Pyrimidine nucleoside phosphorylase-like, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pyrimidine nucleoside phosphorylase-like, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Thymidine phosphorylase. [EC: 2.4.2.4]
Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.
  • In some tissues also catalyzes deoxyribosyltransferase reactions of the type catalyzed by EC 2.4.2.6.
  • Formerly EC 2.4.2.23.
 412 A0A023Z7T2 A0A024L996 A0A025CK83 A0A026V634 A0A028AHE2 A0A028DNS4 A0A029IE91 A0A029J354 A0A045JU97 A0A066RIT9
(402 more...)
AMP phosphorylase. [EC: 2.4.2.57]
(1) AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate. (2) CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate. (3) UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.
  • The enzyme from archaea is involved in AMP metabolism and CO(2) fixation through type III RubisCO enzymes.
  • The activity with CMP and UMP requires activation by cAMP.
 35 A0A075WCU4 A0A075WE03 A0A0E3QJ06 A0A101F129 A0A117L112 A0B6C9 A1RWC3 A2BJU0 A2SPI9 A3CSY4
(25 more...)
Pyrimidine-nucleoside phosphorylase. [EC: 2.4.2.2]
(1) Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. (2) Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. (3) 2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate.
  • Unlike EC 2.4.2.3 and EC 2.4.2.4, this enzyme can accept both the ribonucleoside uridine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine.
  • The reaction is reversible, and the enzyme does not distinguish between alpha-D-ribose 1-phosphate and 2-deoxy-alpha-D-ribose 1-phosphate in the synthetic direction.
  • Formerly EC 2.4.2.23.
 24 A0A0H3K9S0 A0A114PFS0 A0A164US10 A0A1E8WVE9 A0A266CWC8 A0A2T4LKT4 A0A3A5LZD6 A0A3R9X1K5 D4FHN2 L8AWN6
(14 more...)
Ribose 1,5-bisphosphate phosphokinase. [EC: 2.7.4.23]
ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate.
  • This enzyme, found in NAD suppression mutants of Escherichia coli, synthesizes 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) without the participation of EC 2.7.6.1.
  • Ribose, ribose 1-phosphate and ribose 5-phosphate are not substrates, and GTP cannot act as a phosphate donor.
 5 A8IA58 B2AIF3 Q0K3R9 Q16A32 Q46UT0