The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Ribonuclease Inhibitor
".
FunFam 365: Toll-like receptor 5
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Toll-like receptor binding GO:0035325
Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.
|
6 | A0A286Y971 (/IDA) A0A2R3VHK9 (/IDA) A0A2R3VHL5 (/IDA) B3DIN1 (/IDA) F8W3J5 (/IDA) F8W4F1 (/IDA) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
6 | A0A286Y971 (/IDA) A0A2R3VHK9 (/IDA) A0A2R3VHL5 (/IDA) B3DIN1 (/IDA) F8W3J5 (/IDA) F8W4F1 (/IDA) |
|
Interleukin-1 receptor binding GO:0005149
Interacting selectively and non-covalently with the interleukin-1 receptor.
|
1 | O60602 (/IPI) |
|
Interleukin-1 receptor binding GO:0005149
Interacting selectively and non-covalently with the interleukin-1 receptor.
|
1 | Q9JLF7 (/ISO) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q9JLF7 (/IPI) |
There are 12 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Activation of immune response GO:0002253
Any process that initiates an immune response.
|
6 | A0A286Y971 (/IMP) A0A2R3VHK9 (/IMP) A0A2R3VHL5 (/IMP) B3DIN1 (/IMP) F8W3J5 (/IMP) F8W4F1 (/IMP) |
|
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
|
2 | C0LP03 (/IEP) G3V6F8 (/IEP) |
|
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
2 | C0LP03 (/IDA) G3V6F8 (/IDA) |
|
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
2 | C0LP03 (/IEP) G3V6F8 (/IEP) |
|
MyD88-dependent toll-like receptor signaling pathway GO:0002755
Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
|
1 | O60602 (/TAS) |
|
Positive regulation of interleukin-8 production GO:0032757
Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
|
1 | O60602 (/IDA) |
|
Positive regulation of interleukin-8 production GO:0032757
Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
|
1 | Q9JLF7 (/ISO) |
|
Positive regulation of toll-like receptor signaling pathway GO:0034123
Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway.
|
1 | O60602 (/IDA) |
|
Positive regulation of toll-like receptor signaling pathway GO:0034123
Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway.
|
1 | Q9JLF7 (/ISO) |
|
Toll-like receptor 5 signaling pathway GO:0034146
Any series of molecular signals generated as a consequence of binding to toll-like receptor 5.
|
1 | O60602 (/TAS) |
|
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
1 | Q9JLF7 (/ISO) |
|
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
|
1 | O60602 (/IEP) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | C0LP03 (/IDA) G3V6F8 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | O60602 (/TAS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q9JLF7 (/ISO) |