The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ribonuclease Inhibitor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 319: Tyrosine-protein kinase receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Voltage-gated ion channel activity GO:0005244
Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
18 A0A087QHE2 (/ISS) A0A087QHE2 (/ISS) A0A091F0K8 (/ISS) A0A091GRI4 (/ISS) A0A091ID17 (/ISS) A0A091IVP5 (/ISS) A0A091W9L5 (/ISS) A0A093GX78 (/ISS) A0A093J4U8 (/ISS) A0A093P6Z7 (/ISS)
(8 more)
GPI-linked ephrin receptor activity GO:0005004
Combining with a GPI-anchored ephrin to initiate a change in cell activity.
1 Q91987 (/IDA)
Voltage-gated ion channel activity GO:0005244
Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
1 Q91987 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q91987 (/ISS)
Neurotrophin binding GO:0043121
Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.
1 Q91987 (/ISS)
Brain-derived neurotrophic factor binding GO:0048403
Interacting selectively and non-covalently with brain-derived neurotrophic factor.
1 Q91987 (/ISS)
Brain-derived neurotrophic factor-activated receptor activity GO:0060175
Combining with a brain-derived neurotrophic factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 Q91987 (/ISS)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of dendrite extension GO:1903859
Any process that modulates the frequency, rate or extent of dendrite extension.
18 A0A087QHE2 (/ISS) A0A087QHE2 (/ISS) A0A091F0K8 (/ISS) A0A091GRI4 (/ISS) A0A091ID17 (/ISS) A0A091IVP5 (/ISS) A0A091W9L5 (/ISS) A0A093GX78 (/ISS) A0A093J4U8 (/ISS) A0A093P6Z7 (/ISS)
(8 more)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 Q91987 (/ISS)
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
1 Q91987 (/ISS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q91987 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q91987 (/ISS)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q91987 (/ISS)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
1 Q91987 (/ISS)
Central nervous system neuron development GO:0021954
The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
1 Q91987 (/ISS)
Cerebral cortex development GO:0021987
The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
1 Q91987 (/ISS)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 Q91987 (/ISS)
Brain-derived neurotrophic factor receptor signaling pathway GO:0031547
The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands.
1 Q91987 (/ISS)
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
1 Q91987 (/ISS)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
1 Q91987 (/ISS)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
1 Q91987 (/ISS)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 Q91987 (/ISS)
Collateral sprouting GO:0048668
The process in which outgrowths develop from the shafts of existing axons.
1 Q91987 (/IMP)
Positive regulation of collateral sprouting GO:0048672
Any process that activates or increases the frequency, rate or extent of collateral sprouting.
1 Q91987 (/IMP)
Positive regulation of axonogenesis GO:0050772
Any process that activates or increases the frequency, rate or extent of axonogenesis.
1 Q91987 (/ISS)
Regulation of dendrite extension GO:1903859
Any process that modulates the frequency, rate or extent of dendrite extension.
1 Q91987 (/IDA)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q91987 (/ISS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q91987 (/ISS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q91987 (/ISS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q91987 (/ISS)
CATH-Gene3D is a Global Biodata Core Resource Learn more...