The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Ribonuclease Inhibitor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 17: leucine-rich repeat LGI family member 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
18 O95970 (/IPI) O95970 (/IPI) O95970 (/IPI) O95970 (/IPI) O95970 (/IPI) O95970 (/IPI) O95970 (/IPI) O95970 (/IPI) O95970 (/IPI) O95970 (/IPI)
(8 more)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
14 O95970 (/IPI) O95970 (/IPI) O95970 (/IPI) O95970 (/IPI) O95970 (/IPI) O95970 (/IPI) O95970 (/IPI) O95970 (/IPI) O95970 (/IPI) O95970 (/IPI)
(4 more)

There are 32 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of synaptic transmission GO:0050806
Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
20 O95970 (/ISS) O95970 (/ISS) O95970 (/ISS) O95970 (/ISS) O95970 (/ISS) O95970 (/ISS) O95970 (/ISS) O95970 (/ISS) O95970 (/ISS) O95970 (/ISS)
(10 more)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
14 O95970 (/TAS) O95970 (/TAS) O95970 (/TAS) O95970 (/TAS) O95970 (/TAS) O95970 (/TAS) O95970 (/TAS) O95970 (/TAS) O95970 (/TAS) O95970 (/TAS)
(4 more)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
14 O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP)
(4 more)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
14 O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP)
(4 more)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
14 O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP) O95970 (/IMP)
(4 more)
Myelination GO:0042552
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
6 B0CM14 (/IDA) B3DJS9 (/IDA) F1R662 (/IDA) Q2HPG2 (/IDA) Q6P0D2 (/IDA) Q8K1S1 (/IDA)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
3 B0CM14 (/IMP) Q2HPG2 (/IMP) Q6P0D2 (/IMP)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
3 B0CM14 (/IMP) Q2HPG2 (/IMP) Q6P0D2 (/IMP)
Brain morphogenesis GO:0048854
The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 B3DJS9 (/IMP) F1R662 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q9JIA1 (/ISO)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
1 Q8K1S1 (/IMP)
Glial cell proliferation GO:0014009
The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others.
1 Q8K1S1 (/IDA)
Schwann cell development GO:0014044
The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.
1 Q8K1S1 (/IMP)
Regulation of exocytosis GO:0017157
Any process that modulates the frequency, rate or extent of exocytosis.
1 Q8K406 (/IDA)
Glial cell development GO:0021782
The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
1 Q8K1S1 (/IMP)
Myelination in peripheral nervous system GO:0022011
The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
1 Q8K1S1 (/IMP)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
1 Q9JIA1 (/ISO)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q9JIA1 (/ISO)
Regulation of myelination GO:0031641
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
1 Q8K1S1 (/IDA)
Regulation of myelination GO:0031641
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
1 Q8N135 (/IMP)
Regulation of myelination GO:0031641
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
1 Q8K1S1 (/ISO)
Regulation of myelination GO:0031641
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
1 Q8K1S1 (/ISS)
Gliogenesis GO:0042063
The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.
1 Q8K1S1 (/IGI)
Gliogenesis GO:0042063
The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.
1 Q8K1S1 (/IMP)
Neuron maturation GO:0042551
A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state.
1 Q8K1S1 (/IMP)
Myelination GO:0042552
The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
1 Q8K1S1 (/IMP)
Positive regulation of synaptic transmission GO:0050806
Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
1 Q8K4Y5 (/IDA)
Positive regulation of synaptic transmission GO:0050806
Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
1 Q9JIA1 (/ISO)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 Q8K4Y5 (/IDA)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 Q9JIA1 (/ISO)
Neurotransmitter receptor localization to postsynaptic specialization membrane GO:0099645
A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).
1 Q9JIA1 (/IDA)
Neurotransmitter receptor localization to postsynaptic specialization membrane GO:0099645
A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).
1 Q9JIA1 (/IMP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
21 O95970 (/TAS) O95970 (/TAS) O95970 (/TAS) O95970 (/TAS) O95970 (/TAS) O95970 (/TAS) O95970 (/TAS) O95970 (/TAS) O95970 (/TAS) O95970 (/TAS)
(11 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
7 Q1EGL2 (/ISS) Q1EGL2 (/ISS) Q5E9T6 (/ISS) Q5E9T6 (/ISS) Q5R945 (/ISS) Q8K4Y5 (/ISS) Q9JIA1 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 Q8K1S1 (/IDA) Q8K4Y5 (/IDA) Q9JIA1 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q8K4Z0 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q9JIA1 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q8K4Y5 (/NAS)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
1 Q8K406 (/IDA)
Synaptic cleft GO:0043083
The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released.
1 Q9JIA1 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q8K4Y5 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q9JIA1 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q9JIA1 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q9JIA1 (/IMP)
CATH-Gene3D is a Global Biodata Core Resource Learn more...