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CATH Superfamily 3.60.20.10

Aminohydrolase, N-terminal nucleophile (Ntn) domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 37: Asparagine synthetase B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Asparagine synthase (glutamine-hydrolyzing) activity GO:0004066
Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate.
 38 P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA)
(28 more)
Asparagine synthase (glutamine-hydrolyzing) activity GO:0004066
Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate.
 38 P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP)
(28 more)
Aspartate-ammonia ligase activity GO:0004071
Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine.
 38 P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA)
(28 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
 38 P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA)
(28 more)
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
 38 P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA)
(28 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 38 P22106 (/IPI) P22106 (/IPI) P22106 (/IPI) P22106 (/IPI) P22106 (/IPI) P22106 (/IPI) P22106 (/IPI) P22106 (/IPI) P22106 (/IPI) P22106 (/IPI)
(28 more)
Asparagine synthase (glutamine-hydrolyzing) activity GO:0004066
Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate.
 6 Q9KTB2 (/ISS) Q9KTB2 (/ISS) Q9KTB2 (/ISS) Q9KTB2 (/ISS) Q9KTB2 (/ISS) Q9KTB2 (/ISS)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Asparagine biosynthetic process GO:0006529
The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid.
 38 P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA)
(28 more)
Asparagine biosynthetic process GO:0006529
The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid.
 38 P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP)
(28 more)
Glutamine metabolic process GO:0006541
The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
 38 P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP)
(28 more)
Cellular amino acid biosynthetic process GO:0008652
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
 38 P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP)
(28 more)
Cellular amino acid catabolic process GO:0009063
The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.
 38 P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP) P22106 (/IMP)
(28 more)
Asparagine biosynthetic process GO:0006529
The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid.
 6 Q9KTB2 (/ISS) Q9KTB2 (/ISS) Q9KTB2 (/ISS) Q9KTB2 (/ISS) Q9KTB2 (/ISS) Q9KTB2 (/ISS)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 38 P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA)
(28 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 38 P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA) P22106 (/IDA)
(28 more)