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CATH Superfamily 3.60.130.10

Clavaminate synthase-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Clavaminate synthase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 12 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Taurine dioxygenase. [EC: 1.14.11.17]
Taurine + 2-oxoglutarate + O(2) = sulfite + aminoacetaldehyde + succinate + CO(2).
  • The enzyme from Escherichia coli also acts on pentanesulfonate, 3-(N-morpholino)propanesulfonate and 2-(1,3-dioxoisoindolin-2- yl)ethanesulfonate, but at lower rates.
 25 A0A070SXX1 A0A093FRJ5 A0A0E1T3C7 A0A0M7MPH8 A0A1X3IRQ1 A0A1X3J5V3 A0A402RWV1 B1LIQ1 D6J6U6 D7XXP9
(15 more...)
Gamma-butyrobetaine dioxygenase. [EC: 1.14.11.1]
4-trimethylammoniobutanoate + 2-oxoglutarate + O(2) = 3-hydroxy-4- trimethylammoniobutanoate + succinate + CO(2).
    		 10 A0A2J8P4G6 A0A2R9B329 G3R1Y7 O75936 P80193 Q19000 Q5R5D8 Q924Y0 Q98KK0 Q9QZU7
    Trimethyllysine dioxygenase. [EC: 1.14.11.8]
    N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O(2) = (3S)-3- hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO(2).
      		 10 A0A0B0ED33 A5DCB6 K7DHL4 L8IA16 Q0VC74 Q5F4B3 Q91ZE0 Q91ZW6 Q96UB1 Q9NVH6
      L-asparagine oxygenase. [EC: 1.14.11.39]
      L-asparagine + 2-oxoglutarate + O(2) = (2S,3S)-3-hydroxyasparagine + succinate + CO(2).
      • The enzyme is only able to hydroxylate free L-asparagine.
      • It is not active toward D-asparagine.
      • The beta-hydroxylated asparagine produced is incorporated at position 9 of the calcium-dependent antibiotic (CDA), an 11-residue non- ribosomally synthesized acidic lipopeptide lactone.
      • Formerly EC 1.14.11.n1.
      		 6 A0A1H2BCA2 A0A2P7ZFY3 A0A397QPN4 A0A3E0GFI3 D6ES33 Q9Z4Z5
      (S)-dichlorprop dioxygenase (2-oxoglutarate). [EC: 1.14.11.43]
      (1) (S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O(2) = 4-chloro-2-methylphenol + pyruvate + succinate + CO(2). (2) (S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O(2) = 2,4- dichlorophenol + pyruvate + succinate + CO(2).
      • The enzymes from the Gram-negative bacteria Delftia acidovorans MC1 and Sphingomonas herbicidovorans MH are involved in the degradation of the (S)-enantiomer of the phenoxyalkanoic acid herbicides mecoprop and dichlorprop.
      		 5 A0A086P5W7 G9FC95 P83309 Q208A9 Q700X4
      Xanthine dioxygenase. [EC: 1.14.11.48]
      Xanthine + 2-oxoglutarate + O(2) = urate + succinate + CO(2).
      • The enzyme, which was characterized from fungi, is specific for xanthine.
      		 5 A0A0B0DL73 C8VSZ2 O74885 Q4QZZ9 Q7SEI7
      (R)-dichlorprop dioxygenase (2-oxoglutarate). [EC: 1.14.11.44]
      (1) (R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O(2) = 4-chloro-2-methylphenol + pyruvate + succinate + CO(2). (2) (R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O(2) = 2,4- dichlorophenol + pyruvate + succinate + CO(2).
      • The enzymes from the Gram-negative bacteria Delftia acidovorans MC1 and Sphingomonas herbicidovorans MH are involved in the degradation of the (R)-enantiomer of the phenoxyalkanoic acid herbicides mecoprop and dichlorprop.
      		 4 G9FCB0 P83310 Q8KSC8 Q8KSC9
      Pentalenolactone F synthase. [EC: 1.14.11.36]
      Pentalenolactone D + 2 2-oxoglutarate + 2 O(2) = pentalenolactone F + 2 succinate + 2 CO(2) + H(2)O.
      • Isolated from the bacteria Streptomyces exfoliatus, Streptomyces arenae and Streptomyces avermitilis.
      • Part of the pentalenolactone biosynthesis pathway.
      		 3 E3VWI8 E3VWK4 Q82IY7
      Clavaminate synthase. [EC: 1.14.11.21]
      (1) Deoxyamidinoproclavaminate + 2-oxoglutarate + O(2) = amidinoproclavaminate + succinate + CO(2). (2) Proclavaminate + 2-oxoglutarate + O(2) = dihydroclavaminate + succinate + CO(2) + H(2)O. (3) Dihydroclavaminate + 2-oxoglutarate + O(2) = clavaminate + succinate + CO(2) + H(2)O.
      • Catalyzes three separate oxidative reactions in the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus.
      • The first step (hydroxylation) is separated from the latter two (oxidative cyclization and desaturation) by the action of EC 3.5.3.22.
      • The three reactions are all catalyzed at the same nonheme iron site.
      		 3 E2PWJ7 Q05581 Q05582
      (5R)-carbapenem-3-carboxylate synthase. [EC: 1.14.20.3]
      (3S,5S)-carbapenam-3-carboxylate + 2-oxoglutarate + O(2) = (5R)-carbapen- 2-em-3-carboxylate + succinate + CO(2) + H(2)O.
      • The enzyme is involved in the biosynthesis of the carbapenem beta- lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum.
      • It catalyzes a stereoinversion at C(5) and introduces a double bond between C-2 and C-3.
      		 2 A0A086ES95 Q9XB59
      L-arginine hydroxylase. [EC: 1.14.11.41]
      L-arginine + 2-oxoglutarate + O(2) = (3S)-3-hydroxy-L-arginine + succinate + CO(2).
      • The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin.
      • It differs from EC 1.14.20.7, because it does not form guanidine and (S)-1-pyrroline-5-carboxylate from 3-hydroxy-L-arginine.
      		 2 C7Q942 Q6WZB0
      Enduracididine beta-hydroxylase. [EC: 1.14.11.40]
      L-enduracididine + 2-oxoglutarate + O(2) = (3S)-3-hydroxy-L- enduracididine + succinate + CO(2).
      • The enzyme is involved in biosynthesis of the nonproteinogenic amino acid beta-hydroxyenduracididine, a component of the mannopeptimycins (cyclic glycopeptide antibiotic), produced by Streptomyces hygroscopicus NRRL 30439.
      		 1 Q643C1