The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Endonuclease/exonuclease/phosphatase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 12: nocturnin isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
2 O35710 (/IDA) O35710 (/IDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
2 Q9ET55 (/ISS) Q9UK39 (/ISS)
Poly(A)-specific ribonuclease activity GO:0004535
Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
2 O35710 (/IDA) O35710 (/IDA)
Poly(A)-specific ribonuclease activity GO:0004535
Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
2 O35710 (/IMP) O35710 (/IMP)
Poly(A)-specific ribonuclease activity GO:0004535
Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
2 Q9ET55 (/ISS) Q9UK39 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O35710 (/IPI) O35710 (/IPI)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear-transcribed mRNA poly(A) tail shortening GO:0000289
Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
7 A0A0B4KH43 (/IMP) A0A0C4DHA6 (/IMP) A8JQX3 (/IMP) C0PPK5 (/IMP) Q3ZAP4 (/IMP) Q6AWF6 (/IMP) Q8MTZ6 (/IMP)
Response to light stimulus GO:0009416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
7 A0A0B4KH43 (/IMP) A0A0C4DHA6 (/IMP) A8JQX3 (/IMP) C0PPK5 (/IMP) Q3ZAP4 (/IMP) Q6AWF6 (/IMP) Q8MTZ6 (/IMP)
Locomotor rhythm GO:0045475
The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.
7 A0A0B4KH43 (/IMP) A0A0C4DHA6 (/IMP) A8JQX3 (/IMP) C0PPK5 (/IMP) Q3ZAP4 (/IMP) Q6AWF6 (/IMP) Q8MTZ6 (/IMP)
Deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0000290
Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length.
2 O35710 (/IGI) O35710 (/IGI)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
2 O35710 (/IEP) O35710 (/IEP)
Response to extracellular stimulus GO:0009991
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
2 O35710 (/IDA) O35710 (/IDA)
Response to extracellular stimulus GO:0009991
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
2 Q9ET55 (/ISS) Q9UK39 (/ISS)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 O35710 (/IMP) O35710 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q9ET55 (/ISS) Q9UK39 (/ISS)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 O35710 (/IDA) O35710 (/IDA)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 Q9ET55 (/ISS) Q9UK39 (/ISS)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
2 O35710 (/IMP) O35710 (/IMP)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
2 Q9ET55 (/ISS) Q9UK39 (/ISS)
Cytoplasmic mRNA processing body assembly GO:0033962
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
2 O35710 (/IGI) O35710 (/IGI)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
2 O35710 (/IMP) O35710 (/IMP)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
2 Q9ET55 (/ISS) Q9UK39 (/ISS)
Positive regulation of fat cell differentiation GO:0045600
Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
2 O35710 (/IMP) O35710 (/IMP)
Positive regulation of fat cell differentiation GO:0045600
Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
2 Q9ET55 (/ISS) Q9UK39 (/ISS)
Negative regulation of osteoblast differentiation GO:0045668
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.
2 O35710 (/IMP) O35710 (/IMP)
Negative regulation of osteoblast differentiation GO:0045668
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.
2 Q9ET55 (/ISS) Q9UK39 (/ISS)
Regulation of embryonic development GO:0045995
Any process that modulates the frequency, rate or extent of embryonic development.
2 O35710 (/IMP) O35710 (/IMP)
MRNA stabilization GO:0048255
Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules.
2 O35710 (/IMP) O35710 (/IMP)
MRNA stabilization GO:0048255
Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules.
2 Q9ET55 (/ISS) Q9UK39 (/ISS)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
1 Q9UK39 (/TAS)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 Q9UK39 (/TAS)
Regulation of embryonic development GO:0045995
Any process that modulates the frequency, rate or extent of embryonic development.
1 Q9ET55 (/ISS)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 A0A0B4KH43 (/IDA) A0A0C4DHA6 (/IDA) A8JQX3 (/IDA) C0PPK5 (/IDA) O35710 (/IDA) O35710 (/IDA) Q3ZAP4 (/IDA) Q6AWF6 (/IDA) Q8MTZ6 (/IDA)
CCR4-NOT complex GO:0030014
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.
7 A0A0B4KH43 (/IDA) A0A0C4DHA6 (/IDA) A8JQX3 (/IDA) C0PPK5 (/IDA) Q3ZAP4 (/IDA) Q6AWF6 (/IDA) Q8MTZ6 (/IDA)
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
2 O35710 (/IDA) O35710 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O35710 (/IDA) O35710 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9ET55 (/ISS) Q9UK39 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9ET55 (/ISS) Q9UK39 (/ISS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 O35710 (/IDA) O35710 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 Q9ET55 (/ISS) Q9UK39 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9UK39 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9UK39 (/TAS)