The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
GroEL
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: T-complex protein 1 subunit zeta

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 O77622 (/IPI) P40227 (/IPI) P40227 (/IPI) P40227 (/IPI) P40227 (/IPI) P40227 (/IPI) P80317 (/IPI) P80317 (/IPI) Q3MHS9 (/IPI) Q6AYJ7 (/IPI)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
6 P39079 (/IDA) P39079 (/IDA) P39079 (/IDA) P39079 (/IDA) P39079 (/IDA) P39079 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
5 P40227 (/HDA) P40227 (/HDA) P40227 (/HDA) P40227 (/HDA) P40227 (/HDA)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
5 P40227 (/TAS) P40227 (/TAS) P40227 (/TAS) P40227 (/TAS) P40227 (/TAS)
WD40-repeat domain binding GO:0071987
Interacting selectively and non-covalently with a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain.
5 P40227 (/IPI) P40227 (/IPI) P40227 (/IPI) P40227 (/IPI) P40227 (/IPI)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
2 Q386I7 (/ISA) Q386I7 (/ISA)
WD40-repeat domain binding GO:0071987
Interacting selectively and non-covalently with a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain.
2 P80317 (/ISO) P80317 (/ISO)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
1 O94515 (/ISO)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
6 P39079 (/IDA) P39079 (/IDA) P39079 (/IDA) P39079 (/IDA) P39079 (/IDA) P39079 (/IDA)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
5 P40227 (/TAS) P40227 (/TAS) P40227 (/TAS) P40227 (/TAS) P40227 (/TAS)
Positive regulation of telomere maintenance via telomerase GO:0032212
Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
5 P40227 (/IMP) P40227 (/IMP) P40227 (/IMP) P40227 (/IMP) P40227 (/IMP)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
5 P40227 (/IMP) P40227 (/IMP) P40227 (/IMP) P40227 (/IMP) P40227 (/IMP)
Positive regulation of establishment of protein localization to telomere GO:1904851
Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere.
5 P40227 (/IMP) P40227 (/IMP) P40227 (/IMP) P40227 (/IMP) P40227 (/IMP)
Positive regulation of protein localization to Cajal body GO:1904871
Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body.
5 P40227 (/HMP) P40227 (/HMP) P40227 (/HMP) P40227 (/HMP) P40227 (/HMP)
Positive regulation of telomerase RNA localization to Cajal body GO:1904874
Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body.
5 P40227 (/HMP) P40227 (/HMP) P40227 (/HMP) P40227 (/HMP) P40227 (/HMP)
Toxin transport GO:1901998
The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 P80317 (/IMP) P80317 (/IMP) Q61390 (/IMP) Q61390 (/IMP)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
2 Q386I7 (/ISA) Q386I7 (/ISA)
Binding of sperm to zona pellucida GO:0007339
The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.
2 P80317 (/IDA) P80317 (/IDA)
Positive regulation of telomere maintenance via telomerase GO:0032212
Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
2 P80317 (/ISO) P80317 (/ISO)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
2 P80317 (/ISO) P80317 (/ISO)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
2 Q386I7 (/ISA) Q386I7 (/ISA)
Positive regulation of establishment of protein localization to telomere GO:1904851
Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere.
2 P80317 (/ISO) P80317 (/ISO)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
1 Q9VXQ5 (/HMP)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
1 O94515 (/ISO)
Centriole replication GO:0007099
The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0.
1 Q9VXQ5 (/IMP)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
1 Q9M888 (/IEP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 A0A1D8PMN9 (/IMP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 Q9M888 (/IEP)

There are 22 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chaperonin-containing T-complex GO:0005832
A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.
17 O94515 (/IDA) P39079 (/IDA) P39079 (/IDA) P39079 (/IDA) P39079 (/IDA) P39079 (/IDA) P39079 (/IDA) P40227 (/IDA) P40227 (/IDA) P40227 (/IDA)
(7 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
14 A0A024RDL1 (/IDA) A0A024RDL1 (/IDA) A0A024RDL1 (/IDA) A0A024RDL1 (/IDA) A0A024RDL1 (/IDA) P40227 (/IDA) P40227 (/IDA) P40227 (/IDA) P40227 (/IDA) P40227 (/IDA)
(4 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 O77622 (/TAS) P40227 (/TAS) P40227 (/TAS) P40227 (/TAS) P40227 (/TAS) P40227 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P40227 (/TAS) P40227 (/TAS) P40227 (/TAS) P40227 (/TAS) P40227 (/TAS)
Chaperonin-containing T-complex GO:0005832
A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.
5 P40227 (/TAS) P40227 (/TAS) P40227 (/TAS) P40227 (/TAS) P40227 (/TAS)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
5 P40227 (/IDA) P40227 (/IDA) P40227 (/IDA) P40227 (/IDA) P40227 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
5 P40227 (/HDA) P40227 (/HDA) P40227 (/HDA) P40227 (/HDA) P40227 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P80317 (/ISO) P80317 (/ISO) Q61390 (/ISO) Q61390 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q386I7 (/IDA) Q386I7 (/IDA) Q9M888 (/IDA)
Chaperonin-containing T-complex GO:0005832
A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.
3 O77622 (/ISS) Q5RCD2 (/ISS) Q76NU3 (/ISS)
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
2 P80317 (/IDA) P80317 (/IDA)
Zona pellucida receptor complex GO:0002199
A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction.
2 P80317 (/IDA) P80317 (/IDA)
Chaperonin-containing T-complex GO:0005832
A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.
2 Q386I7 (/ISA) Q386I7 (/ISA)
Chaperonin-containing T-complex GO:0005832
A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.
2 P80317 (/ISO) P80317 (/ISO)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
2 P80317 (/ISO) P80317 (/ISO)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
2 P80317 (/IDA) P80317 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O94515 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q4QFY8 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O94515 (/HDA)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
1 O94515 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9M888 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 Q76NU3 (/HDA)