The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
FAD/NAD(P)-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 64: Thioredoxin reductase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Thioredoxin-disulfide reductase activity GO:0004791
Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide.
25 C8V4E8 (/IDA) C8V4E8 (/IDA) O22229 (/IDA) O22229 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA)
(15 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
13 O22229 (/IPI) O22229 (/IPI) P29509 (/IPI) P29509 (/IPI) P29509 (/IPI) P29509 (/IPI) P29509 (/IPI) P29509 (/IPI) P29509 (/IPI) P29509 (/IPI)
(3 more)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
9 P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA)
Thioredoxin-disulfide reductase activity GO:0004791
Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide.
3 O22229 (/IMP) O22229 (/IMP) Q92375 (/IMP)
Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor GO:0016671
Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide.
3 O22229 (/IDA) O22229 (/IDA) Q70G58 (/IDA)
Thioredoxin-disulfide reductase activity GO:0004791
Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide.
2 Q39243 (/ISS) Q54UU8 (/ISS)
Thioredoxin-disulfide reductase activity GO:0004791
Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide.
2 C8V4E8 (/RCA) C8V4E8 (/RCA)
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
2 O22229 (/IDA) O22229 (/IDA)
Thioredoxin-disulfide reductase activity GO:0004791
Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide.
1 Q5AG89 (/IGI)
Thioredoxin-disulfide reductase activity GO:0004791
Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide.
1 Q39242 (/ISA)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
1 Q5AG89 (/IGI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q70G58 (/IPI)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
12 O22229 (/IDA) O22229 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA)
(2 more)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
10 P29509 (/IGI) P29509 (/IGI) P29509 (/IGI) P29509 (/IGI) P29509 (/IGI) P29509 (/IGI) P29509 (/IGI) P29509 (/IGI) P29509 (/IGI) Q5AG89 (/IGI)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
9 P29509 (/IMP) P29509 (/IMP) P29509 (/IMP) P29509 (/IMP) P29509 (/IMP) P29509 (/IMP) P29509 (/IMP) P29509 (/IMP) P29509 (/IMP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
8 P38816 (/IMP) P38816 (/IMP) P38816 (/IMP) P38816 (/IMP) P38816 (/IMP) P38816 (/IMP) P38816 (/IMP) P38816 (/IMP)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
8 P38816 (/IC) P38816 (/IC) P38816 (/IC) P38816 (/IC) P38816 (/IC) P38816 (/IC) P38816 (/IC) P38816 (/IC)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
3 C8V4E8 (/IEP) C8V4E8 (/IEP) Q5AG89 (/IEP)
Nucleobase-containing compound metabolic process GO:0006139
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
2 C8V4E8 (/RCA) C8V4E8 (/RCA)
Regulation of chlorophyll biosynthetic process GO:0010380
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors.
2 O22229 (/IMP) O22229 (/IMP)
Regulation of starch biosynthetic process GO:0010581
An process which modulate the frequency, rate or extent of starch biosynthesis, the chemical reactions and pathways resulting in the formation of starch.
2 O22229 (/IMP) O22229 (/IMP)
Hydrogen peroxide catabolic process GO:0042744
The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
2 O22229 (/IMP) O22229 (/IMP)
Positive regulation of catalytic activity GO:0043085
Any process that activates or increases the activity of an enzyme.
2 O22229 (/IDA) O22229 (/IDA)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 Q54UU8 (/IMP)
Removal of superoxide radicals GO:0019430
Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2).
1 Q92375 (/IC)
Culmination involved in sorocarp development GO:0031154
The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development.
1 Q54UU8 (/IMP)
Hydrogen peroxide catabolic process GO:0042744
The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
1 Q70G58 (/IDA)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
1 Q5AG89 (/IGI)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
1 Q54UU8 (/ISS)
Positive regulation of cell division GO:0051781
Any process that activates or increases the frequency, rate or extent of cell division.
1 Q39243 (/IGI)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
17 P29509 (/HDA) P29509 (/HDA) P29509 (/HDA) P29509 (/HDA) P29509 (/HDA) P29509 (/HDA) P29509 (/HDA) P29509 (/HDA) P29509 (/HDA) P38816 (/HDA)
(7 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) Q39243 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
9 P38816 (/IDA) P38816 (/IDA) P38816 (/IDA) P38816 (/IDA) P38816 (/IDA) P38816 (/IDA) P38816 (/IDA) P38816 (/IDA) Q39243 (/IDA)
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
9 P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA) P29509 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
3 O22229 (/IDA) O22229 (/IDA) Q70G58 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
2 O22229 (/IDA) O22229 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q92375 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q92375 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q92375 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q5AG89 (/IGI)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
1 Q39243 (/IDA)
Fungal biofilm matrix GO:0062040
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
1 Q5AG89 (/IDA)