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CATH Superfamily 3.50.50.60

FAD/NAD(P)-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
FAD/NAD(P)-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 126: 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic a...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-(3-hydroxy-phenyl)propanoic acid hydroxylase. [EC: 1.14.13.127]
(1) 3-(3-hydroxyphenyl)propanoate + NADH + O(2) = 3-(2,3- dihydroxyphenyl)propanoate + H(2)O + NAD(+). (2) (2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + O(2) = (2E)-3-(2,3- dihydroxyphenyl)prop-2-enoate + H(2)O + NAD(+).
  • This enzyme participates in a meta-cleavage pathway employed by the bacterium Escherichia coli for the degradation of various phenylpropanoid compounds.
  • Formerly EC 1.14.13.n3.
 433 A0A029IB03 A0A029IB03 A0A029IB03 A0A029IB03 A0A029J1L0 A0A029J1L0 A0A029J1L0 A0A029J1L0 A0A037Y2B6 A0A037Y2B6
(423 more...)
Resorcinol 4-hydroxylase (NADH). [EC: 1.14.13.220]
Resorcinol + NADH + O(2) = hydroxyquinol + NAD(+) + H(2)O.
  • The enzyme, characterized from the bacterium Rhodococcus jostii RHA1, is a single-component hydroxylase.
  • The enzyme has no activity with NADPH.
  • Cf. EC 1.14.13.219 and EC 1.14.14.27.
 1 Q0SFL5
4-nitrophenol 4-monooxygenase. [EC: 1.14.13.167]
4-nitrophenol + NADPH + O(2) = 1,4-benzoquinone + nitrite + NADP(+) + H(2)O.
  • The enzyme catalyzes the first step in a degradation pathway for 4-nitrophenol, the oxidation of 4-nitrophenol at position 4 with the concomitant removal of the nitro group as nitrite.
  • The enzyme from the bacterium Pseudomonas sp. WBC-3 also catalyzes EC 1.14.13.166.
 1 C1I201