The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Hepatocyte Growth Factor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Plasminogen

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 24 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
4 A6PVI2 (/IPI) P00747 (/IPI) P06868 (/IPI) Q5TEH5 (/IPI)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
4 A6PVI2 (/IPI) P00747 (/IPI) P06868 (/IPI) Q5TEH5 (/IPI)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
2 P00747 (/IDA) Q01177 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P00747 (/IPI) P06868 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 P00747 (/IPI) Q01177 (/IPI)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
2 P00747 (/IPI) P20918 (/IPI)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
1 P20918 (/ISO)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
1 P00747 (/IDA)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
1 P00747 (/IMP)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
1 P20918 (/ISO)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
1 P00747 (/TAS)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P20918 (/ISO)
Serine-type peptidase activity GO:0008236
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
1 P00747 (/TAS)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P20918 (/ISO)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
1 P20918 (/ISO)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 P20918 (/ISO)
Apolipoprotein binding GO:0034185
Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex.
1 P00747 (/IPI)
Apolipoprotein binding GO:0034185
Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex.
1 P20918 (/ISO)
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
1 P00747 (/IPI)
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
1 P20918 (/ISO)
Proteasome core complex binding GO:1904854
Interacting selectively and non-covalently with a proteasome core complex.
1 P00747 (/IPI)
Proteasome core complex binding GO:1904854
Interacting selectively and non-covalently with a proteasome core complex.
1 P20918 (/ISO)
Protein antigen binding GO:1990405
Interacting selectively and non-covalently with a protein antigen.
1 P00747 (/IPI)
Protein antigen binding GO:1990405
Interacting selectively and non-covalently with a protein antigen.
1 P20918 (/ISO)

There are 41 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Interaction with symbiont via secreted substance involved in symbiotic interaction GO:0052213
An interaction with the symbiont organism mediated by a substance secreted by the other (host) organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.
2 P00747 (/IDA) P06867 (/IDA)
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
1 P00747 (/TAS)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 P00747 (/IDA)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 P00747 (/IMP)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 P20918 (/ISO)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 P00747 (/IMP)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 P20918 (/ISO)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 P20918 (/ISS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P00747 (/TAS)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
1 P06868 (/IDA)
Negative regulation of cell-substrate adhesion GO:0010812
Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
1 P00747 (/IDA)
Negative regulation of cell-substrate adhesion GO:0010812
Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
1 P20918 (/ISO)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
1 P20918 (/TAS)
Extracellular matrix disassembly GO:0022617
A process that results in the breakdown of the extracellular matrix.
1 P00747 (/IDA)
Extracellular matrix disassembly GO:0022617
A process that results in the breakdown of the extracellular matrix.
1 P20918 (/ISO)
Extracellular matrix disassembly GO:0022617
A process that results in the breakdown of the extracellular matrix.
1 P00747 (/TAS)
Tissue regeneration GO:0042246
The regrowth of lost or destroyed tissues.
1 P20918 (/IMP)
Fibrinolysis GO:0042730
A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin.
1 P00747 (/IDA)
Fibrinolysis GO:0042730
A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin.
1 P20918 (/ISO)
Fibrinolysis GO:0042730
A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin.
1 P00747 (/TAS)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
1 P00747 (/TAS)
Myoblast differentiation GO:0045445
The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
1 P20918 (/IMP)
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
1 P20918 (/IMP)
Proteolysis involved in cellular protein catabolic process GO:0051603
The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
1 Q01177 (/IDA)
Proteolysis involved in cellular protein catabolic process GO:0051603
The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
1 P20918 (/ISO)
Interaction with symbiont GO:0051702
An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.
1 P00747 (/IDA)
Interaction with symbiont GO:0051702
An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.
1 P20918 (/ISO)
Negative regulation of fibrinolysis GO:0051918
Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
1 P00747 (/IDA)
Negative regulation of fibrinolysis GO:0051918
Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
1 P20918 (/ISO)
Positive regulation of fibrinolysis GO:0051919
Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
1 P00747 (/IDA)
Positive regulation of fibrinolysis GO:0051919
Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
1 P20918 (/ISO)
Modification by host of symbiont morphology or physiology via secreted substance GO:0052182
The process in which an organism effects a change in the structure or function of a symbiont organism, mediated by a substance secreted by one of the organisms. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.
1 P00747 (/IDA)
Modification by host of symbiont morphology or physiology via secreted substance GO:0052182
The process in which an organism effects a change in the structure or function of a symbiont organism, mediated by a substance secreted by one of the organisms. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.
1 P00747 (/IMP)
Modification by host of symbiont morphology or physiology via secreted substance GO:0052182
The process in which an organism effects a change in the structure or function of a symbiont organism, mediated by a substance secreted by one of the organisms. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.
1 P20918 (/ISO)
Interaction with symbiont via secreted substance involved in symbiotic interaction GO:0052213
An interaction with the symbiont organism mediated by a substance secreted by the other (host) organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.
1 P20918 (/ISO)
Trophoblast giant cell differentiation GO:0060707
The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua.
1 P20918 (/IMP)
Labyrinthine layer blood vessel development GO:0060716
The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply.
1 P20918 (/IMP)
Mononuclear cell migration GO:0071674
The movement of a mononuclear cell within or between different tissues and organs of the body.
1 P20918 (/IMP)
Trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183
Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of brain derived neurotrophic factor (BDNF), that modulates the synaptic transmission properties of the synapse.
1 P20918 (/IDA)
Trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183
Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of brain derived neurotrophic factor (BDNF), that modulates the synaptic transmission properties of the synapse.
1 P20918 (/IMP)
Negative regulation of cell-cell adhesion mediated by cadherin GO:2000048
Any process that stops, prevents, or reduces the frequency, rate or extent of cell-cell adhesion mediated by cadherin.
1 P00747 (/TAS)

There are 25 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P00747 (/TAS) P20918 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P00747 (/IDA) Q01177 (/IDA)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
2 P00747 (/HDA) P20918 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P00747 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P20918 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P20918 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q01177 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P20918 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P00747 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P00747 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P20918 (/ISO)
Extrinsic component of plasma membrane GO:0019897
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 P20918 (/IDA)
Platelet alpha granule lumen GO:0031093
The volume enclosed by the membrane of the platelet alpha granule.
1 P00747 (/TAS)
Extrinsic component of external side of plasma membrane GO:0031232
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.
1 P00747 (/IDA)
Extrinsic component of external side of plasma membrane GO:0031232
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.
1 P20918 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q01177 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 P20918 (/ISO)
Other organism cell membrane GO:0044218
The cell membrane of a secondary organism with which the first organism is interacting.
1 P00747 (/IDA)
Other organism cell membrane GO:0044218
The cell membrane of a secondary organism with which the first organism is interacting.
1 P20918 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P00747 (/HDA)
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
1 P00747 (/HDA)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
1 P20918 (/IDA)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
1 P20918 (/IMP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P20918 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P20918 (/IMP)