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CATH Superfamily 3.50.4.10

Hepatocyte Growth Factor

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Hepatocyte Growth Factor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Coagulation factor XI

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Plasma kallikrein. [EC: 3.4.21.34]
Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.
  • Formed from plasma prokallikrein (Fletcher factor) by factor XIIa.
  • Activates coagulation factors XII, VII and plasminogen.
  • Selective for Arg > Lys in P1, in small molecule substrates.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.4.21 and EC 3.4.21.8.
 28 H9H9R5 H9H9R5 H9H9R5 H9H9R5 H9H9R5 H9H9R5 H9H9R5 H9H9R5 P03952 P03952
(18 more...)
Coagulation factor XIa. [EC: 3.4.21.27]
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
  • The proenzyme XI is activated by EC 3.4.21.38.
  • Belongs to peptidase family S1.
 8 P03951 P03951 P03951 P03951 Q91Y47 Q91Y47 Q91Y47 Q91Y47