The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Isopropylmalate Dehydrogenase
".
FunFam 6: 3-isopropylmalate dehydrogenase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
3-isopropylmalate dehydrogenase activity GO:0003862
Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+.
|
6 | P04173 (/IDA) P04173 (/IDA) P04173 (/IDA) P04173 (/IDA) P04173 (/IDA) P04173 (/IDA) |
|
3-isopropylmalate dehydrogenase activity GO:0003862
Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+.
|
6 | P04173 (/IMP) P04173 (/IMP) P04173 (/IMP) P04173 (/IMP) P04173 (/IMP) P04173 (/IMP) |
|
3-isopropylmalate dehydrogenase activity GO:0003862
Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+.
|
4 | Q5B9I7 (/RCA) Q5B9I7 (/RCA) Q5BEW8 (/RCA) Q5BEW8 (/RCA) |
|
3-isopropylmalate dehydrogenase activity GO:0003862
Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+.
|
1 | P18869 (/IGI) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q5SIY4 (/IPI) |
There are 6 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Leucine biosynthetic process GO:0009098
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
|
8 | A0A1D8PQK5 (/IMP) A0A1D8PQK5 (/IMP) P04173 (/IMP) P04173 (/IMP) P04173 (/IMP) P04173 (/IMP) P04173 (/IMP) P04173 (/IMP) |
|
Glyoxylate cycle GO:0006097
A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
|
6 | P04173 (/IMP) P04173 (/IMP) P04173 (/IMP) P04173 (/IMP) P04173 (/IMP) P04173 (/IMP) |
|
Branched-chain amino acid metabolic process GO:0009081
The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
|
4 | Q5B9I7 (/RCA) Q5B9I7 (/RCA) Q5BEW8 (/RCA) Q5BEW8 (/RCA) |
|
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
|
2 | A0A1D8PQK5 (/IMP) A0A1D8PQK5 (/IMP) |
|
Leucine biosynthetic process GO:0009098
The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.
|
1 | P18869 (/IGI) |
|
Coenzyme B biosynthetic process GO:0019298
The chemical reactions and pathways resulting in the formation of coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes.
|
1 | Q58991 (/IDA) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
6 | P04173 (/IDA) P04173 (/IDA) P04173 (/IDA) P04173 (/IDA) P04173 (/IDA) P04173 (/IDA) |
|
Fungal biofilm matrix GO:0062040
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
|
2 | A0A1D8PQK5 (/IDA) A0A1D8PQK5 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P18869 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P18869 (/IGI) |