The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Isopropylmalate Dehydrogenase
".
FunFam 12: Homoisocitrate dehydrogenase, mitochondrial
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Homoisocitrate dehydrogenase activity GO:0047046
Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate.
|
10 | P40495 (/IDA) P40495 (/IDA) P40495 (/IDA) P40495 (/IDA) P40495 (/IDA) P40495 (/IDA) P40495 (/IDA) P40495 (/IDA) P40495 (/IDA) Q5A9D9 (/IDA) |
|
Homoisocitrate dehydrogenase activity GO:0047046
Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate.
|
3 | G5EB15 (/RCA) G5EB15 (/RCA) G5EB15 (/RCA) |
|
Homoisocitrate dehydrogenase activity GO:0047046
Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate.
|
1 | O14104 (/ISS) |
|
NAD binding GO:0051287
Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
|
1 | Q5A9D9 (/IDA) |
There are 5 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Lysine biosynthetic process GO:0009085
The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid.
|
9 | P40495 (/IC) P40495 (/IC) P40495 (/IC) P40495 (/IC) P40495 (/IC) P40495 (/IC) P40495 (/IC) P40495 (/IC) P40495 (/IC) |
|
Lysine metabolic process GO:0006553
The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid.
|
3 | G5EB15 (/IMP) G5EB15 (/IMP) G5EB15 (/IMP) |
|
Lysine metabolic process GO:0006553
The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid.
|
3 | G5EB15 (/RCA) G5EB15 (/RCA) G5EB15 (/RCA) |
|
Lysine biosynthetic process GO:0009085
The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid.
|
1 | Q5A9D9 (/IDA) |
|
Lysine biosynthetic process GO:0009085
The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid.
|
1 | O14104 (/IMP) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
9 | P40495 (/HDA) P40495 (/HDA) P40495 (/HDA) P40495 (/HDA) P40495 (/HDA) P40495 (/HDA) P40495 (/HDA) P40495 (/HDA) P40495 (/HDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | O14104 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | O14104 (/ISS) |